Unraveling the molecular crossroads:T2DM and Parkinson’s disease interactions  

作　　者：TINGTING LIU XIANGRUI KONG JIANSHE WEI 

机构地区：[1]Institute for Brain Sciences Research,School of Life Sciences,Henan University,Kaifeng,475004,China

出　　处：《BIOCELL》2024年第12期1735-1749,共15页生物细胞（英文）

基　　金：supported partly by National Natural Science Foundation of China(32161143021,81271410);Henan University Graduate«Talent Program»of Henan Province(SYLYC2023092);Henan Natural Science Foundation of China(182300410313).

摘　　要：Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by persistent hyperglycemia.In recent times,an elevated risk of Parkinson’s disease(PD)development among individuals with T2DM has become evident.However,the molecular mechanisms that underpin the interplay between T2DM and the pathogenesis of PD remain to be elucidated.Nevertheless,recent epidemiological studies have underscored several shared molecular pathways that are crucial for normal cellular function and are also associated with the progression and etiology of both T2DM and PD.This review encapsulates some of the shared pathophysiological mechanisms,including genetic risk factors,hyperglycemia,insulin resistance(IR),inflammation,mitochondrial dysfunction,oxidative stress,autophagy,and advanced glycation end products(AGEs),which independently contribute to the onset and progression of T2DM and PD.Additionally,this review compiles studies that have investigated the relationship between T2DM and PD.This review aims to offer insights into the overlapping molecular pathways involved,which may suggest alternative therapeutic strategies for both T2DM and PD.

关 键 词：Type 2 diabetes mellitus Parkinson’s disease Oxidative stress Mitochondrial dysfunction AUTOPHAGY 

分 类 号：R587.1[医药卫生—内分泌] R742.5[医药卫生—内科学]