Advances in the diagnosis and treatment of symptomatic intracranial atherosclerotic disease  

作　　者：Hongrui Ma Xunming Ji 

机构地区：[1]Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China

出　　处：《Journal of Translational Neuroscience》2024年第4期1-13,共13页转化神经科学电子杂志（英文）

摘　　要：Intracranial atherosclerotic disease(ICAD)manifests systemic atherosclerosis in the intra-cranial arterial bed.It is the most common risk factor for ischemic stroke in Chinese population,with symptomatic ICAD(sICAD)patients at higher stroke risk.Continuous cerebral hypoperfusion and hemodynamic decompensa-tion caused by arterial stenosis or occlusion are the main pathological mechanisms for stroke recurrence and cog-nitive impairment in sICAD patients.Despite receiving reinforced medical therapy,about 10%of sICAD patients still suffer stroke recurrence.Blood flow reconstruction techniques are not yet established as routine stroke pre-vention for sICAD due to complex perioperative com-plications.Limb remote ischemic conditioning(LRIC)can effectively reduce the incidence of ischemic stroke,and composite cerebrovascular diseases,and improve ce-rebral perfusion,brain metabolism,and cerebrovascular reserve(CVR)in sICAD patients,serving as a novel ther-apeutic strategy.However,the protective mechanisms of LRIC and the optimal treatment regimen for sICAD still require further exploration.Exploring imaging biomark-ers with high sensitivity and specificity for diagnosis is of great significance in evaluating and predicting stroke risk in sICAD patients.

关 键 词：intracranial atherosclerotic disease STROKE DIAGNOSIS TREATMENT HEMODYNAMICS 

分 类 号：R543.1[医药卫生—心血管疾病] R743.3[医药卫生—内科学]