PF4 and CXCL5 as potential diagnostic biomarkers and therapeutic targets for Parkinson’s disease complicated by ulcerative colitis  

作　　者：Jie Li Weiwei Yang Ming Zhou Shengli Xu 

机构地区：[1]Department of Neurology,Beijing Daxing District Hospital of Integrated Chinese and Western Medicine,Beijing 100076,China [2]Department of Neurobiology,Neurology and Geriatrics,Xuanwu Hospital,Capital Medical University,National Clinical Research Center for Geriatric Disorders,Beijing 100053,China [3]Key Laboratory for Neurodegenerative Disease of the Ministry of Education,Beijing Key Laboratory for Parkinson’s Dis-ease,Parkinson Disease Center of Beijing Institute for Brain Disorders,Beijing 100053,China

出　　处：《Journal of Translational Neuroscience》2024年第4期32-46,共15页转化神经科学电子杂志（英文）

摘　　要：While accumulating evidence indicates a relationship between ulcerative colitis (UC) and Parkin-son’s disease (PD), the interactions between them have not been thoroughly examined. In this study we explored their association via genetic characterization and function-al enrichment. Assessment and validation were conducted in a novel dataset comprising whole blood RNA sequenc-ing (RNAseq) data and in three datasets retrieved from the Gene Expression Omnibus database (GSE107499, GSE75214, and GSE100054). Weighted gene co-expres-sion network analysis was used to determine the most rel-evant differentially expressed genes (DEGs) for the clin-ical features. Hub genes were identified using molecular complex detection (MCODE) application. In the training and validation datasets, we found two hub genes plate-let factor 4 (PF4) and C-X-C motif chemokine ligand 5 (CXCL5), which showed significant upregulation in all four datasets. The receiver operating characteristic curve indicated a diagnostic role for PF4 and CXCL5 in UC and PD. Therefore, PF4 and CXCL5 may provide key insights into the relationship between UC and PD.

关 键 词：ulcerative colitis Parkinson’s disease weighted gene co-expression network analysis immune cell infiltration hub gene 

分 类 号：R742.5[医药卫生—神经病学与精神病学]