米非司酮联合维生素D治疗子宫肌瘤患者的疗效观察  

Effect of Mifepristone combined with vitamin D on patients with uterine fibroids

作　　者：李兰[1] 王炎林 王敏[1] 王海云 李佳玲 雍敏 LI Lan;WANG Yan-lin;WANG Min;WANG Hai-yun;LI Jia-ling;YONG Min(不详;Nanchong Central Hospital,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院,南充市637000 [2]川北医学院 [3]南充市中心医院

出　　处：《妇产与遗传（电子版）》2024年第1期16-19,共4页Obstetrics-Gynecology and Genetics (Electronic Edition)

基　　金：南充市社会科学研究“十四五”规划2022年度项目(NC22C348);川北医学院校级科研发展计划项目(CBY21-QA65)。

摘　　要：目的 探索米非司酮联合维生素D保守治疗子宫肌瘤的临床价值。方法 收集于川北医学院附属医院2020年1月至2021年12月要求保守治疗的子宫肌瘤患者,并检测其血清维生素D浓度;将血清维生素D <20 nmol/L的120例子宫肌瘤患者作为研究对象。按照随机数字表法分为实验组与对照组,各60例。对照组接受米非司酮治疗,实验组接受米非司酮联合维生素D治疗。统计学分析两组治疗后的临床效果以及子宫肌瘤变化。结果 治疗前,实验组与对照组的子宫肌瘤大小差异无统计学意义(P> 0.05)。治疗后,两组子宫肌瘤大小均小于治疗前,且差异有统计学意义(P=0.001,P=0.001);且治疗后实验组的子宫肌瘤大小显著低于对照组,差异有统计学意义(P=0.001),实验组总有效率明显高于对照组,差异有统计学意义(P=0.011)。结论 米非司酮可缩小子宫肌瘤体积,抑制子宫肌瘤生长。维生素D可增强米非司酮的子宫肌瘤生长抑制效应。维生素D联合米非司酮可以作为抑制子宫肌瘤生长的潜在治疗方案。Objective To explore the clinical value of mifepristone combined with vitamin D in the treatment of uterine fibroids.Methods patients with uterine fibroids requiring conservative treatment from January 2020 to December 2021 in the Affiliated Hospital of Chuanbei Medical College were collected and their serum vitamin D was detected.120 patients with uterine fibroids whose serum vitamin D<20 nmol/L were studied.They were divided into experimental group and control group according to random number table method,60 cases each.The control group received mifepristone and the experimental group received mifepristone combined with vitamin D.The clinical effects as well as changes of uterine fibroids after treatment in both groupswere analyzed statistically.Results Before treatment,there was no significant difference in the size of uterine fibroids between experimental group and control group(P>0.05).After treatment,the size of uterine fibroids in both groups were smaller than that before treatment,and the difference was statistically significant(P=0.001,P=0.001).The size of uterine fibroids in the experimental group was significantly lower than that in the control group after treatment,and the difference was statistically significant(P=0.0010),and the total effective rate in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P=0.011).Conclusions Mifepristone reduces fibroid size and inhibits fibroid growth.Vitamin D may enhance the fibroid growth inhibitory effect of mifepristone.Vitamin D combined with mifepristone serve as a potential treatment for inhibiting the growth of uterine fibroids.

关 键 词：子宫肌瘤 维生素D 米非司酮 临床疗效 

分 类 号：R737.3[医药卫生—肿瘤]