高压氧治疗对脑卒中患者神经功能、纤维蛋白原和空腹血糖的影响  

Effects of hyperbaric oxygen therapy on neurological function,fibrinogen,and fasting blood glucose of stroke patients

作　　者：王鹏飞[1] 吴壮填 熊丽华 谭杰文[4] 朱颉[1,2] Wang Pengfei;Wu Zhuangtian;Xiong Lihua;Tan Jiewen;Zhu Jie(Department of Emergency,Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 510120,China;Emergency Department,Shenshan Medical Center,Memorial Hospital of Sun Yat-sen University,Shanwei 516400,China;Department of Pediatrics,Shenshan Medical Center,Memorial Hospital of Sun Yat-sen University,Shanwei 516400,China;Department of Rehabilitation,Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院急诊科,广州510120 [2]中山大学孙逸仙纪念医院深汕中心医院急诊科,汕尾516400 [3]中山大学孙逸仙纪念医院深汕中心医院儿科,汕尾516400 [4]中山大学孙逸仙纪念医院康复科,广州510120

出　　处：《中华航海医学与高气压医学杂志》2024年第6期723-727,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：广州市科技计划项目(2023A04J2094)。

摘　　要：目的观察高压氧(HBO)治疗对脑卒中患者神经功能、纤维蛋白原和空腹血糖的影响。方法前瞻性选取2022年9月至2023年6月中山大学孙逸仙纪念医院深汕中心医院收治的66例脑卒中患者为研究对象,按照治疗方法分为HBO治疗组(n=40)和常规治疗组(n=26)。比较2组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)、基础性日常生活活动能力(BADL)评分及纤维蛋白原、空腹血糖的变化。结果与治疗前相比,2组患者治疗后NIHSS评分明显降低[(7.68±6.64)分、(5.35±3.91)分vs.(6.03±4.71)分、(4.92±3.54)分],BADL评分明显升高[(43.75±28.03)分、(56.54±24.85)分vs.(60.88±24.98)分、(58.65±26.37)分],HBO治疗组患者纤维蛋白原[(3.73±1.15)g/L vs.(3.08±0.97)g/L]及空腹血糖[(6.19±2.01)mmol/L vs.(5.28±0.85)mmol/L]水平明显降低,差异均有统计学意义(P<0.05或P<0.01);治疗后与常规治疗组相比,HBO治疗组患者的NIHSS、BADL评分及纤维蛋白原水平变化更明显,差异均有统计学意义(P<0.05或P<0.01)。结论HBO治疗可促进脑卒中患者的神经功能恢复,改善日常生活活动能力、纤维蛋白原及空腹血糖水平。Objective To investigate the effects of hyperbaric oxygen(HBO)therapy on neurological function,fibrinogen,and fasting blood glucose of stroke patients.Methods A total of 66 stroke patients admitted to Shenshan Medical Center of Memorial Hospital of Sun Yat-sen University from September 2022 to June 2023 were prospectively selected as research subjects and divided into an HBO group(n=40)and a conventional treatment group(n=26).The National Institutes of Health stroke scale(NIHSS),basic activities of daily living(BADL),and levels of fibrinogen and fasting blood glucose were compared before and after treatment within each group as well as between groups.Results Compared with those before treatment,both groups exhibited significant reductions in NIHSS scores[(7.68±6.64)points,(5.35±3.91)points vs.(6.03±4.71)points,(4.92±3.54)points]and notable increases in BADL[(43.75±28.03)points,(56.54±24.85)points vs.(60.88±24.98)points,(58.65±26.37)points]scores after treatment.In the HBO group,there were marked decreases in fibrinogen and fasting blood glucose levels[(3.73±1.15)g/L,(6.19±2.01)mmol/L vs.(3.08±0.97)g/L,(5.28±0.85)mmol/L]all with statistically significant differences(P<0.05 or P<0.01).Furthermore,after treatment,when the HBO group was compared with the conventional treatment group,the improvements in NIHSS and BADL scores,as well as the reduction in fibrinogen levels,were more obvious,all with statistically significant differences(P<0.05 or P<0.01).Conclusion HBO can promote the recovery of neurological function in stroke patients,improve the ability to perform activities of daily living,and ameliorate the levels of fibrinogen and fasting blood glucose.

关 键 词：脑卒中 美国国立卫生研究院卒中量表 基础性日常生活活动能力 纤维蛋白原 血糖 高压氧治疗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]