高压氧联合多奈哌齐治疗阿尔茨海默病疗效及对血清humanin和内皮素1水平的影响  

Efficacy of hyperbaric oxygen combined with donepezil in the treatment of Alzheimer’s disease and its impact on the levels of serum humanin and endothelin-1

作　　者：沈丽丽 徐杰 Shen Lili;Xu Jie(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;The First Rehabilitation Hospital in Shanghai,Shanghai 200090,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030 [2]上海市第一康复医院,上海200090

出　　处：《中华航海医学与高气压医学杂志》2024年第6期747-751,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨高压氧联合多奈哌齐治疗阿尔茨海默病(AD)的临床疗效,以及其对患者血清humanin、内皮素1(ET-1)水平的影响。方法选取2021年1月至2024年1月在上海交通大学医学院附属精神卫生中心治疗的AD患者98例,按照随机数字表法分为对照组与观察组,每组49例。对照组给予盐酸多奈哌齐治疗,观察组在对照组治疗方案的基础上联合高压氧治疗,2组均治疗7周。比较2组患者治疗前后AD评估量表认知部分(ADAS-cog)、简易智能精神状态量表(MMSE)、蒙特利尔认知量表(MoCA)、神经精神科问卷(NPI)、日常生活活动量表(ADL)评分,血清humanin、ET-1水平,以及不良反应发生率。结果治疗后观察组患者MMSE和MoCA评分高于对照组,ADAS-cog评分低于对照组,差异均有统计学意义(P<0.05)。治疗前2组患者NPI和ADL评分差异无统计学意义(P>0.05);治疗后观察组患者ADL评分高于对照组,NPI评分低于对照组,差异均有统计学意义(P<0.05)。治疗前2组患者血清humanin、ET-1水平差异无统计学意义(P>0.05);治疗后观察组患者血清humanin水平高于对照组,ET-1水平低于对照组,差异均有统计学意义(P<0.05)。观察组和对照组总不良反应发生率分别为12.24%(6/49)和10.20%(5/49),差异无统计学意义(P>0.05)。结论高压氧联合多奈哌齐治疗AD的效果优于单用多奈哌齐,能提高患者血清humanin水平、降低ET-1水平,改善AD患者认知功能和精神障碍,提高其日常生活活动能力,并且治疗安全性较好。Objective To investigate the efficacy of hyperbaric oxygen combined with donepezil in the treatment of Alzheimer’s disease(AD),and its effects on serum humanin and endothelin-1(ET-1).Methods A total of 98 patients with AD treated in Shanghai Mental Health Center of Shanghai Jiao Tong University School of Medicine from January 2021 to January 2024 were selected and randomly divided into a control group and an observation group according to the random number table method.The control group was treated with donepezil hydrochloride,while the observation group was treated with hyperbaric oxygen therapy on the basis of the treatment in the control group.Both groups were treated for 7 weeks.The scores of the cognition part of the AD assessment scale(ADAS-cog),the mini-mental state examination(MMSE),the Montreal cognitive assessment(MoCA),the neuropsychiatric inventory(NPI),the activities of daily living(ADL)before and after treatment,as well as the levels of serum humanin and ET-1,efficacy,and incidence of adverse reactions were compared.Results After treatment,the MMSE and MoCA scores of the observation group were higher than those of the control group,and the ADAS-cog score was lower than that of the control group,and the differences were all statistically significant(P<0.05).Before treatment,there was no statistically significant difference in NPI and ADL scores between the two groups of patients(P>0.05).After treatment,the ADL score of the observation group was higher than that of the control group,and the NPI score was lower than that of the control group,and the differences were both statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of serum humanin and ET-1 between the two groups of patients(P>0.05).After treatment,the serum humanin level of the observation group was higher than that of the control group,and the ET-1 level was lower than that of the control group,and the differences were both statistically significant(P<0.05).The total incidence of

关 键 词：阿尔茨海默病 高压氧 多奈哌齐 HUMANIN 内皮素 认知功能 

分 类 号：R749.16[医药卫生—神经病学与精神病学]