蛋白酶激活受体2在胃食管反流病相关炎症反应中的分子机制研究进展  

Advances in molecular mechanisms of protease-activated receptor 2 in inflammation associated with gastroesophageal reflux disease

作　　者：苏拉依曼·牙库甫 李义亮[1,2,3] 艾克拜尔·艾力 克力木·阿布都热依木[1,2,3] Sulayiman Yakufu;Li Yiliang;Aikebaier Aili;Kelimu Abudureyimu(Minimally Invasive,Hernia and Abdominal,Wall Surgery Department,Xinjiang Uygur Autonomous Region People′s Hospital,Urumqi 830002,China;Xinjiang Uygur Autonomous Region General Surgery Minimally Xinjiang Clinical Medical Research Center of Gastroesophageal Reflux Disease and Weight Loss and Invasive Research Institute,Urumqi 830002,China;Xinjiang Uygur Autonomous Region General Surgery Minimally Invasive Research Institute,Urumqi 830002,China)

机构地区：[1]新疆维吾尔自治区人民医院微创疝和腹壁外科,乌鲁木齐830002 [2]新疆胃食管反流病与减重代谢外科临床医学研究中心,乌鲁木齐830002 [3]新疆维吾尔自治区普通外科微创研究所,乌鲁木齐830002

出　　处：《中国医师杂志》2024年第12期1911-1915,共5页Journal of Chinese Physician

基　　金：国家自然科学基金(82060166);新疆维吾尔自治区重点研发专项-厅厅联动基金资助项目(2023B03010-3)。

摘　　要：蛋白酶激活受体(PAR)是G蛋白偶联受体家族成员之一,它包括四个亚型,分别为PAR1、PAR2、PAR3、PAR4,除PAR2胰蛋白酶受体外,其他亚基都属于凝血酶受体。这些受体广泛存在于机体各组织中,尤其是在消化系统中发挥一定的生物学效应。近十年来研究显示PAR1、PAR2在免疫炎症反应中起着关键的作用,引起了人们的重视。目前探讨PAR2独特的激活方式在胃食管反流病(GERD)食管黏膜损害,疼痛的传导中的免疫炎症反应,应激等病理过程中对研究疾病的发展具有一定的临床价值。本综述旨在阐述PAR2在胃食管炎症反应中的分子机制。Protease activating receptor(PAR)is a member of G protein-coupled receptor family,which includes four subtypes,namely PAR1,PAR2,PAR3 and PAR4.Except PAR2 trypsin receptor,other subunits belong to thrombin receptor.These receptors exist widely in various tissues of the body,especially in the digestive system to play a certain biological effect.In recent ten years,studies have shown that PAR1 and PAR2 play a key role in immune inflammatory response,which has aroused people′s attention.At present,it is of clinical value to study the development of gastroesophageal reflux disease(GERD)by exploring the unique activation mode of PAR2 in the pathological processes of esophageal mucosal damage,pain transmission,immune inflammatory response,stress and so on.This review aims to elucidate the molecular mechanism of PAR2 in gastroesophageal inflammation.

关 键 词：受体 蛋白酶激活 受体 PAR-2 胃食管反流 

分 类 号：R571[医药卫生—消化系统]