驱动蛋白家族成员3A在恶性肿瘤发生和发展中的作用研究进展  

Research progress on the role of KIF3A in the genesis and development of malignant tumors

作　　者：蒋彦峰 王平安 薛栋[1] Jiang Yanfeng;Wang Pingan;Xue Dong(Department of Hepatobiliary Surgery,Binzhou People′s Hospital,Binzhou 256600,China)

机构地区：[1]滨州市人民医院肝胆外科,滨州256600

出　　处：《中国医师杂志》2024年第12期1915-1920,共6页Journal of Chinese Physician

基　　金：山东省自然科学基金(ZR2022MH303);山东省医药卫生科技发展计划项目(202104010675,202004011131);滨州市人民医院院级课题(YJKTZR202105,XJ2022007708)。

摘　　要：驱动蛋白家族成员3A(KIF3A)是驱动蛋白家族的一个重要成员,在细胞分裂过程中主要参与双极有丝分裂纺锤体的构建。KIF3A在肿瘤组织中广泛表达,在细胞分裂中发挥重要生物学功能,与肿瘤的形成关系密切,是多种恶性肿瘤的预后因子。因此KIF3A可能成为肿瘤靶向治疗的一个新的靶点。本文总结了近年来对KIF3A的研究现状,重点综述其分子结构、生物学功能、与肿瘤的关系及信号传导通路分子机制。Kinesin Family Member 3A(KIF3A)is an important member of the kinesin family,which is mainly involved in the construction of bipolar mitotic spindle during cell division.KIF3A is widely expressed in tumor tissues,plays an important biological function in cell division,is closely related to tumor formation,and is a prognostic factor for a variety of malignant tumors.Therefore,KIF3A may become a new target for tumor targeted therapy.In this review,the current research status of KIF3A in recent years was summarized,focusing on the relationship between its molecular structure,biological function and tumor,and the molecular mechanism of signal transduction pathway.

关 键 词：驱动蛋白 KIF3A 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]