认知行为疗法联合度洛西汀、坦度螺酮治疗广泛性焦虑障碍的效果  

Effect of Cognitive Behavioral Therapy Combined with Duloxetine and Tandospirone in the Treatment of Generalized Anxiety Disorder

作　　者：吕瑰敏 孙娜 朱晓雨 姬超 LYU Guimin;SUN Na;ZHU Xiaoyu;JI Chao(Department of Psychology,Zibo Hospital of Integrated Traditional Chinese and Western Medicine,Zibo 255000,China;不详)

机构地区：[1]淄博市中西医结合医院神志科,山东淄博255000 [2]淄博市精神卫生中心精神科,山东淄博255000

出　　处：《中国医学创新》2025年第1期6-10,共5页Medical Innovation of China

摘　　要：目的:探讨度洛西汀、坦度螺酮联合认知行为疗法(cognitive behavior therapy,CBT)对广泛性焦虑障碍(generalized anxiety disorder,GAD)的临床治疗效果及对大脑神经递质的影响。方法:选取2021年11月—2023年11月在淄博市中西医结合医院住院的GAD患者100例,随机分为治疗组和对照组,每组50例。治疗组在度洛西汀、坦度螺酮治疗基础上联合CBT治疗,对照组则接受度洛西汀、坦度螺酮和常规心理治疗。治疗6周后,比较两组患者的汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分及脑γ-GABA等神经递质的功率。结果:治疗6周后,治疗组与对照组的HAMA、HAMD评分均较治疗前明显下降(P<0.05);治疗组的HAMA、HAMD评分均低于对照组(P<0.05)。治疗6周后,治疗组治疗有效率高于对照组(P<0.05)。治疗6周后,治疗组与对照组的γ-GABA、5-HT、NE功率均较治疗前明显提高(P<0.05),治疗组的γ-GABA、5-HT、NE功率与对照组比较差异均无统计学意义(P>0.05)。结论:在度洛西汀、坦度螺酮基础上,CBT治疗GAD的效果要明显优于常规心理治疗,能更好地缓解患者焦虑抑郁症状,提升临床疗效。Objective:To investigate the clinical effect of Duloxetine and Tandospirone combined with cognitive behavioral therapy(CBT)on generalized anxiety disorder(GAD)and its effects on neurotransmitters in the brain.Method:A total of 100 patients with GAD hospitalized in Zibo Hospital of Integrated Traditional Chinese and Western Medicine from November 2021 to November 2023 were randomly divided into treatment group and control group,with 50 cases in each group.The treatment group received combination therapy with CBT on the basis of Duloxetine and Tanshinone,while the control group received Duloxetine,Tanshinone,and conventional psychological therapy.After 6 weeks of treatment,the scores of Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)and the power analysis of brain neurotransmitters such asγ-GABA were compared between the two groups.Result:After 6 weeks of treatment,HAMA and HAMD scores in the treatment group and the control group were significantly decreased compared with those before treatment(P<0.05);HAMA and HAMD scores in the treatment group were lower than those in the control group(P<0.05).The effective rate of treatment in the treatment group was significantly higher than that in the control group after 6 weeks of treatment(P<0.05).After 6 weeks of treatment,the power analysis ofγ-GABA,5-HT and NE in the treatment group and the control group were significantly higher than those before treatment(P<0.05),the power analysis ofγ-GABA,5-HT and NE in the treatment group had no significant differences compared with the control group(P>0.05).Conclusion:On the basis of Duloxetine and Tanshinone,the effect of CBT in treating GAD is significantly better than conventional psychological therapy,which can better alleviate patients'anxiety and depression symptoms and improve clinical efficacy.

关 键 词：广泛性焦虑障碍 认知行为疗法 神经递质 

分 类 号：R749.72[医药卫生—神经病学与精神病学]