益生菌联合雷贝拉唑四联疗法治疗幽门螺杆菌阳性慢性糜烂性胃炎的效果  

Effect of Probiotics Combined with Rabeprazole Quadruple Therapy on Chronic Erosive Gastritis with Helicobacter Pylori Positive

作　　者：罗贤云 官海云 LUO Xianyun;GUAN Haiyun(Department of Gastroenterology,Guangfeng District People's Hospital of Shangrao,Shangrao 334600,China;不详)

机构地区：[1]上饶市广丰区人民医院消化内科,江西上饶334600

出　　处：《中国医学创新》2025年第1期31-34,共4页Medical Innovation of China

摘　　要：目的:探讨益生菌与雷贝拉唑四联疗法联合治疗幽门螺杆菌(Helicobacter pylori,Hp)阳性慢性糜烂性胃炎(chronic erosive gastritis,CEG)的效果。方法:按随机数字表法将2020年1月—2021年12月上饶市广丰区人民医院收治的100例Hp阳性CEG患者分为两组,各50例。对照组采用雷贝拉唑四联疗法,观察组采用益生菌(双歧杆菌三联活菌)+雷贝拉唑四联疗法治疗,两组均持续治疗2周。对两组治疗效果、症状消失时间(反酸、上腹隐痛及嗳气)、胃黏膜评分、Hp根除率进行评估,并统计不良反应发生情况。结果:观察组治疗总有效率[94.00%(47/50)]较对照组[72.00%(36/50)]高(P<0.05);观察组反酸消失时间[(10.42±2.77)d]、上腹隐痛消失时间[(10.69±2.89)d]及嗳气消失时间[(6.93±1.62)d]均较对照组[(14.06±3.09)、(14.32±3.10)、(9.12±1.88)d]早,差异均有统计学意义(P<0.05);治疗后,观察组胃黏膜评分为(0.71±0.21)分,低于对照组的(1.06±0.32)分,差异有统计学意义(P<0.05);观察组Hp根除率明显高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:Hp阳性CEG患者采用益生菌与雷贝拉唑四联疗法联合治疗的效果显著,可促进胃黏膜修复,提高Hp根除率,改善患者临床症状,且不增加不良反应发生风险。Objective:To investigate the effect of probiotics combined with Rabeprazole quadruple therapy on chronic erosive gastritis(CEG)with Helicobacter pylori(Hp)positive.Method:A total of 100 patients with CEG with Hp positive admitted to Guangfeng District People's Hospital of Shangrao from January 2020 to December 2021 were divided into two groups according to random number table method,with 50 cases in each group.The control group was treated with Rabeprazole quadruple therapy,and the observation group was treated with probiotics(Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules)+Rabeprazole quadruple therapy.Both groups were treated continuously for 2 weeks.The therapeutic effect,symptoms disappearance time(acid reflux,upper abdominal dull pain and belching),gastric mucosa score and Hp eradication rate of the two groups were evaluated,and the incidence of adverse reactions were counted.Result:The total effective rate of observation group[94.00%(47/50)]was higher than that of control group[72.00%(36/50)](P<0.05).The disappearance time of acid reflux[(10.42±2.77)d],upper abdominal dull pain[(10.69±2.89)d]and belching[(6.93±1.62)d]in the observation group were earlier than those in the control group[(14.06±3.09),(14.32±3.10),(9.12±1.88)d],the differences were statistically significant(P<0.05).After treatment,the gastric mucosa score in the observation group was(0.71±0.21)scores,which was lower than(1.06±0.32)scores in the control group,the difference was statistically significant(P<0.05).The eradication rate of Hp in observation group was significantly higher than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of probiotics and Rabeprazole quadruple therapy in the treatment of patients with CEG with Hp positive has a significant effect,which can promote the repair of gastric mucosa,improve the eradication rate of Hp and improve the clinical symptoms of patients,and do not incre

关 键 词：慢性糜烂性胃炎 益生菌 雷贝拉唑 四联疗法 不良反应 

分 类 号：R573.3[医药卫生—消化系统]