野黄芩苷联合用药抗肿瘤机制研究进展  

Research progress on anti-tumor mechanism of scutellarin combined with drugs

作　　者：鲍颖霞 周玉婷 郭睿智 陈新[3] 陈忠豪 杨阳 王一如 王健松 BAO Yingxia;ZHOU Yuting;GUO Ruizhi;CHEN Xin;CHEN Zhonghao;YANG Yang;WANG Yiru;WANG Jiansong(Guangzhou Baiyunshan Pharmaceutical Holdings Co.,Ltd.Baiyunshan Pharmaceutical General Factory,Guangdong Key Laboratory for Core Technology of Chemical Raw Materials and Pharmaceutical Formulations,Guangdong,Guangzhou 510515,China;Guangdong University of Technology,Guangdong,Guangzhou 510006,China;University of Macao,Macao 999078,China)

机构地区：[1]广州白云山医药集团股份有限公司白云山制药总厂、广东省化学药原料与制剂关键技术研究重点实验室,广东广州510515 [2]广东工业大学,广东广州510006 [3]澳门大学,中国澳门999078

出　　处：《中国医药科学》2024年第23期44-47,共4页China Medicine And Pharmacy

基　　金：广东省省级科技计划项目(2023A0505030012)。

摘　　要：野黄芩苷是一种天然的黄酮类化合物,具有抗氧化,抗纤维化、抗炎、改善心脑缺血等多种药理活性,主要用于脑卒中、冠心病和心绞痛等心脑血管疾病的防治。此外,大量研究证实野黄芩苷单用具有抗肿瘤活性,对非小细胞肺癌、乳腺癌、结直肠癌、卵巢癌和肝癌等具有一定的治疗作用。近年来,野黄芩苷与其他药物联合运用抗肿瘤的策略也越来越受到重视,其作用机制包括抑制肿瘤细胞增殖、诱导细胞凋亡、抑制肿瘤细胞的侵袭和转移、提高肿瘤耐药细胞对化疗药物的敏感性、诱导肿瘤细胞自噬等。本文综述野黄芩苷联用抗肿瘤的作用及分子机制,为其进一步开发利用提供科学依据。Scutellarin is a natural flavonoid,which has many pharmacological activities,such as anti-oxidation,anti-fibrosis,anti-inflammation,and alleviating cardiac and cerebral ischemia.It is mainly used for the prevention and treatment of cardiovascular and cerebrovascular diseases such as stroke,coronary heart disease and angina pectoris.In addition,a large number of studies have confirmed that scutellarin alone has anti-tumor activity and has certain therapeutic efficacies on non-small cell lung cancer,breast cancer,colorectal cancer,ovarian cancer and liver cancer.In recent years,more and more attention has been paid to the anti-tumor strategy of scutellarin combined with other drugs.Its function mechanism includes inhibiting the proliferation of tumor cells,inducing apoptosis,inhibiting the invasion and metastasis of tumor cells,improving the sensitivity of tumor-resistant cells to chemotherapy drugs,and inducing autophagy of tumor cells.In this paper,the anti-tumor function and molecular mechanism of combined scutellarin are reviewed,so as to provide scientific basis for its further development and utilization.

关 键 词：野黄芩苷 灯盏花乙素 联合用药 抗肿瘤 作用机制 

分 类 号：R735.1[医药卫生—肿瘤]