液体活检在乳腺癌中的研究进展  

Advances in liquid biopsy research in breast cancer

作　　者：关家裕 林司杭 周文斌 GUAN Jiayu;LIN Sihang;ZHOU Wenbin(The Second Clinical Medical College of Jinan University,Guangdong,Shenzhen 518020,China;Department of Breast Surgery,Shenzhen People’s Hospital,Guangdong,Shenzhen 518020,China)

机构地区：[1]暨南大学第二临床医学院,广东深圳518020 [2]深圳市人民医院乳腺外科,广东深圳518020

出　　处：《中国医药科学》2024年第23期52-56,共5页China Medicine And Pharmacy

基　　金：深圳市医学重点学科建设经费资助(No.SZXK015)。

摘　　要：近年来,一种新型的肿瘤检测技术——液体活检,因其在精准医学领域展现出的巨大潜力而受到广泛关注。该技术主要通过血液或其他体液样本来检测肿瘤标志物,进而早期识别,评估患者的疗效、疾病进展和预后。本文对其三大检测靶点——循环肿瘤细胞、循环肿瘤DNA和细胞外囊泡的研究现状进行综述,并探讨这项技术在乳腺癌中的临床应用及其局限性,与传统组织活检技术进行对比分析。液体活检能对癌症进行早期诊断,并在癌症进展监测中发挥重要作用。In recent years,a new tumor detection technology,liquid biopsy,has attracted widespread attention for the great potential it shows in the field of precision medicine.This technology mainly detects tumor markers through blood or other body fluid samples,leading to early identification and assessments of efficacy,disease progression and prognosis in patient.In this paper,we will review the current research status of its three major detection targets:circulating tumor cells,circulating tumor DNA and extracellular vesicles.Meanwhile,this study explore the clinical application of this technology in breast cancer and its limitations.A comparative analysis with traditional tissue biopsy techniques will also be conducted.Liquid biopsy enables early diagnosis of cancer and plays an important role in monitoring cancer progression.

关 键 词：液体活检 循环肿瘤细胞 循环肿瘤DNA 细胞外囊泡 组织活检 

分 类 号：R737.9[医药卫生—肿瘤]