2型糖尿病患者甘油三酯葡萄糖乘积指数与非酒精性脂肪性肝病患病风险的相关性研究  

Correlation research between triglyceride and glucose index and risk of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

作　　者：徐瑞君[1] 薛一[1] 周姣姣 杨奇超[1] XU Ruijun;XUE Yi;ZHOU Jiaojiao;YANG Qichao(Wujin Hospital Affiliated to Jiangsu University,Wujin Clinical College of Xuzhou Medical University,Jiangsu,Changzhou 213000,China)

机构地区：[1]江苏大学附属武进医院,徐州医科大学武进临床学院,江苏常州213000

出　　处：《中国医药科学》2024年第23期177-180,共4页China Medicine And Pharmacy

基　　金：江苏省常州市“龙城医星”卫生青年科技人才托举工程(lcyx2023008);江苏省常州市卫健委科技项目(WZ202226)。

摘　　要：目的探讨2型糖尿病(T2DM)患者甘油三酯葡萄糖乘积(TyG)指数与非酒精性脂肪性肝病(NAFLD)患病风险的相关性。方法选择2023年1—12月江苏大学附属武进医院内分泌科的T2DM患者442例,分为NAFLD组(215例)和非NAFLD组(227例),收集患者各项临床数据,计算TyG指数。logistic回归分析TyG水平对患者发生NAFLD的影响。绘制ROC曲线评价TyG水平对T2DM患者发生NAFLD的预测效果。结果与非NAFLD组比较,NAFLD组TyG及多个指标均升高(P<0.05)。多因素logistic回归分析显示,TyG与T2DM患者发生NAFLD独立相关(OR=13.02,95%CI:6.45~26.29,P<0.001)。将TyG数值按照四分位数分层(TyG<8.80=1,8.80~<9.20=2,9.20~<9.83=3,≥9.83=4),结果表明TyG≥8.80为T2DM患者发生NAFLD的独立危险因素(OR>1,P<0.001)。ROC曲线分析显示,TyG预测T2DM患者发生NAFLD最佳截断值为9.21,曲线下面积(AUC)为0.895,Kappa系数为0.605。结论T2DM患者TyG升高与NAFLD的发生密切相关,TyG对NAFLD的发生有较好的预测价值。Objective To investigate the correlation between the triglyceride and glucose(TyG)index and the risk of nonalcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 442 patients with T2DM in the Department of Endocrinology of Wujin Hospital Affiliated to Jiangsu University from January to December 2023 were selected and divided into the NAFLD group(n=215)and the non-NAFLD group(n=227).The clinical data of patients were collected and the TyG index was calculated.The impact of TyG level on NAFLD in patients was analyzed by logistic regression.ROC curve was drawn to evaluate the predictive effect of TyG level on NAFLD in patients with T2DM.Results Compared with the non-NAFLD group,the TyG and several indices in the NAFLD group were all increased(P<0.05).Multivariate Logistic regression analysis showed that TyG was independently correlated with NAFLD in patients with T2DM(OR=13.02,95%CI 6.45~26.29,P<0.001).TyG values were stratified according to quartiles(taking TyG<8.80 as layer 1,taking 8.80≤TyG<9.20 as layer 2,taking 9.20≤TyG<9.83 as layer 3,and taking TyG≥9.83 as layer 4).The results showed that TyG≥8.80 was an independent risk factor for NAFLD in patients with T2DM(OR>1,P<0.001).ROC curve analysis showed that the optimal cutoff value for TyG prediction of NAFLD in patients with T2DM was 9.21.The area under the curve(AUC)was 0.895,and the Kappa coefficient was 0.605.Conclusion The increase of TyG in patients with T2DM is closely correlated to the occurrence of NAFLD,and TyG has a relatively good predictive value for the occurrence of NAFLD.

关 键 词：2型糖尿病 甘油三酯葡萄糖乘积指数 非酒精性脂肪性肝病 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统] R587.2[医药卫生—内科学]