IL-1β与IL-18在胰腺癌患者血清中的表达及临床意义  

作　　者：郑立平 王兢 胡春东 陈徐艰 费发明 沈亦钰 

机构地区：[1]嘉兴大学附属第二医院,314000

出　　处：《浙江临床医学》2024年第12期1807-1810,共4页Zhejiang Clinical Medical Journal

基　　金：嘉兴市科技计划项目(2021AD30091)。

摘　　要：目的探讨白细胞介素1β(IL-1β)、白细胞介素18(IL-18)在胰腺癌患者血清中的表达水平及临床意义。方法采用酶联免疫吸附测定(ELISA)方法检测胰腺癌患者与健康体检者血清中IL-1β、IL-18的表达水平,并分析其与胰腺癌患者临床病理学特征的关系及对患者总生存期的影响。结果胰腺癌患者与健康体检者血清IL-1β、IL-18表达水平比较,差异有统计学意义(P<0.05)。血清IL-1β表达水平越高,胰腺癌患者的肿瘤分化程度越低、淋巴转移越多且TNM分期越晚(P<0.05),而血清IL-18表达水平越高,胰腺癌患者的肿瘤分化程度越高、淋巴转移越少且TNM分期越早(P<0.05)。单因素分析结果显示,血清IL-1β高表达组患者的中位生存期较其对应的低表达组患者明显缩短(P<0.001),而血清IL-18高表达组患者的中位生存期较其对应的低表达组患者明显延长(P<0.05)。多因素分析结果显示,血清IL-1β表达水平为影响胰腺癌患者预后的独立危险因素。结论IL-1β和IL-18在胰腺癌患者血清中高表达,且与肿瘤分化程度、淋巴转移及TNM分期密切相关。血清IL-18表达水平是胰腺癌患者预后的重要因素,而血清IL-1β表达水平是胰腺癌患者预后的独立危险因素。Objective To investigate the expression levels and clinical significance of interleukin-1β(IL-1β)and interleukin-18(IL-18)in serum of patients with pancreatic cancer.Methods Enzyme-linked immunosorbent assay(ELISA)was used to detect the serum levels of IL-1βand IL-18 in patients with pancreatic cancer and healthy controls.The relationship between the serum levels of IL-1βand IL-18 and the clinicopathological characteristics of patients with pancreatic cancer and the effect on the overall survival of patients were analyzed.Results There were significant differences in serum IL-1βand IL-18 levels between patients with pancreatic cancer and healthy controls(P<0.05).The higher the expression level of serum IL-1β,the lower the degree of tumor differentiation,the more lymph node metastasis and the later TNM stage of pancreatic cancer patients(P<0.05).The higher the expression level of serum IL-18,the higher the degree of tumor differentiation,the less lymph node metastasis and the earlier TNM stage of pancreatic cancer patients(P<0.05).Univariate analysis showed that the median survival time of patients with high serum IL-1βexpression was significantly shorter than that of their corresponding low expression group(P<0.001),while the median survival time of patients with high serum IL-18 expression was significantly longer than that of their corresponding low expression group(P<0.05).Multivariate analysis showed that serum IL-1βlevel was an independent risk factor for the prognosis of pancreatic cancer patients.Conclusion IL-1βand IL-18 are highly expressed in the serum of pancreatic cancer patients,and are closely related to the degree of tumor differentiation,lymph node metastasis and TNM stage.The expression level of serum IL-18 is an important factor for the prognosis of pancreatic cancer patients,and the expression level of serum IL-1βis an independent risk factor for the prognosis of pancreatic cancer patient.

关 键 词：白细胞介素1Β 白细胞介素18 胰腺癌 酶联免疫吸附测定 

分 类 号：R735.9[医药卫生—肿瘤]