LZTS2、FN1、miR-146a与甲状腺癌临床病理参数关系研究  

Relationship between LZTS2,FN1,miR-146a and clinicopathologic parameters of thyroid cancer

作　　者：吴静静[1] 张辉[1] WU Jing-jing;ZHANG Hui(Department of Pathology,Anhui Wanbei Coal Power Group General Hospital,Suzhou 234000,China)

机构地区：[1]安徽皖北煤电集团总医院病理科,安徽宿州234000

出　　处：《诊断病理学杂志》2024年第12期1170-1174,共5页Chinese Journal of Diagnostic Pathology

基　　金：2022年度安徽省卫生健康科研项目(AHWJ2022a035)。

摘　　要：目的 分析甲状腺癌组织中亮氨酸拉链肿瘤抑制因子2(LZTS2)、纤连蛋白1(FN1)、微小核糖核酸-146a(miR-146a)差异表达及与临床病理参数的关系。方法 选取2021年1月至2022年12月安徽皖北煤电集团总医院收治的109例甲状腺癌患者作为研究对象。所选患者均接受甲状腺次全切除术或全切除术,并收集患者术中切除的部分癌旁组织和癌组织,比较癌组织和癌旁组织及不同临床病理参数患者癌组织中LZTS2、FN1、miR-146a表达,并分析癌组织中上述各指标之间的相关性。结果 甲状腺癌患者癌组织中LZTS2阳性表达率低于癌旁组织(P<0.05),而FN1阳性表达率及miR-146a表达高于癌旁组织(P<0.05)。与Ⅰ~Ⅱ期、无淋巴结转移者比,LZTS2在Ⅲ~Ⅳ期、有淋巴结转移者癌组织中的阳性表达率更低,FN1阳性表达率及miR-146a表达更高(P<0.05)。癌组织中LZTS2与FN1及miR-146a呈负相关,FN1与miR-146a呈正相关(P<0.05)。结论 甲状腺癌中LZTS2呈低表达,而FN1及miR-146a呈高表达,这些改变可能参与甲状腺癌发生发展过程。Objective To analyze the differential expression of leucine zipper tumor suppressor 2(LZTS2),fibronectin 1(FN1),micro-ribonucleic acid-146a(miR-146a) in thyroid carcinoma tissues and their relationship with clinicopathological features.Methods A total of 109 thyroid cancer patients admitted to Anhui Wanbei Coal and Electricity Group General Hospital from January 2021 to December 2022 were selected as the study subjects.All the selected patients underwent subtotal thyroidectomy or total resection,and some of the paracancerous tissues and cancer tissues resected during surgery were collected.The expression levels of LZTS2,FN1,miR-146a in paracancerous tissues and cancer tissues of patients with different clinicopathologic features were compared.The correlation between the expression levels of LZTS2,FN1,miR-146a in carcinoma tissues was analyzed.Results The positive expression rate of LZTS2 in cancer tissues of thyroid cancer patients was lower than that in paraneoplastic tissues(P < 0.05),while the positive expression rate of FN1 and the expression of miR-146a were higher than that in paraneoplastic tissues(P < 0.05).Compared with patients of stage Ⅰ~Ⅱ without lymph node metastasis,the positive expression rate of LZTS2 in patients of stage Ⅲ~Ⅳ with lymph node metastasis was decreased,while the positive expression rates of FN1,miR-146a were increased(P < 0.05).LZTS2 was negatively correlated with FN1 and miR-146a in the cancer tissues,while FN1 was positively correlated with miR-146a(P < 0.05).Conclusion The expression of LZTS2 is decreaed in patients with thyroid carcinoma tissues,while that of FN1 and miR-146a is increased,which may be involved in the progression of thyroid carcinoma.

关 键 词：甲状腺癌 亮氨酸拉链肿瘤抑制因子2 纤连蛋白1 微小核糖核酸-146a 病理特点 

分 类 号：R736.1[医药卫生—肿瘤] R446.1[医药卫生—临床医学]