高度近视巩膜病理改变特征及相关调控分子  

Characteristics of pathological changes of the sclera in high myopia and related regulatory molecules

作　　者：杨冬梅[1] 梁刚 李俊[1] 赵婧[2] 陈志[2] 周行涛[2] YANG Dongmei;LIANG Gang;LI Jun;ZHAO Jing;CHEN Zhi;ZHOU Xingtao(Affiliated Hospital of Yunnan University,Kunming 650000,Yunnan Province,China;Eye&ENT Hospital,Fudan University,Shanghai 200031,China)

机构地区：[1]云南大学附属医院,云南省昆明市650000 [2]复旦大学附属眼耳鼻喉科医院,上海市200031

出　　处：《眼科新进展》2025年第1期55-59,共5页Recent Advances in Ophthalmology

基　　金：国家重点研究与发展计划[编号:2023YFA0915000(040)];国家自然科学基金项目(编号:82371096)。

摘　　要：高度近视是一种以眼轴过度延长为主要特征的屈光异常。巩膜作为眼轴调控的重要组成部分,在高度近视的发生发展过程中起关键作用。本文将结合国内外文献,从高度近视性巩膜病变的特征及影响巩膜超微结构和机械性能的基因调控、信号通路等方面,系统性总结高度近视巩膜病理改变及相关调控分子,旨在为高度近视的病理机制研究提供理论基础。High myopia is a refractive abnormality characterized by excessive elongation of the eye axis.The sclera,as an important part of the eye axis regulation,plays a key role in the occurrence and development of high myopia.In this paper,based on the domestic and international articles,the pathological changes and related regulatory molecules of the sclera in high myopia were systematically summarized from the features of scleral lesions in high myopia and the gene regulation and signaling pathways affecting the ultrastructure and mechanical properties of the sclera,thus providing a theoretical basis for the study of the pathological mechanism of high myopia.

关 键 词：高度近视 巩膜病变 调控分子 

分 类 号：R778[医药卫生—眼科]