Network pharmacology-based approach to understand the effect and mechanism of Tangzhiqing against atherosclerosis  

作　　者：Sen-Qi Yang Wan-Ying Feng Zhi-Hui Song Xin-Ya Ding Rui Chen Yi Wang 

机构地区：[1]School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China [2]Institute of Traditional Chinese medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China

出　　处：《Natural Therapy Advances》2024年第4期13-20,共8页

基　　金：supported by the Tianjin Education Commission Research Program Project(Grant number:2023KJ123).

摘　　要：Background:Tangzhiqing formula(TZQ)has powerful pharmacological effects on diabetes and hyperlipidemia.However,according to current studies,the action and molecular mechanisms of TZQ for the treatment of atherosclerosis are not fully understood.Methods:In this study,we employed a network pharmacology approach that integrates target prediction,network construction,Gene Ontology(GO)analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis,and molecular docking.This comprehensive methodology was used to predict the potential targets of TZQ in the treatment of atherosclerosis(AS)and to further elucidate the pharmacological mechanisms involved.Results:The targets predicted in this study are all highly involved in the TNF-αsignaling pathway,NOD-like eceptor signaling pathway,apoptotic pathway,etc.APP,NCOA1,ESR1,CCND1,EGRF,RELA,and FOS are the core targets of TZQ regulation and play a central role in its anti-AS effect.Conclusion:This study elucidates the mechanisms of TZQ in treating AS,providing a theoretical foundation for future research.

关 键 词：Tangzhiqing(TZQ) ATHEROSCLEROSIS systems pharmacology DOCKING 

分 类 号：R285[医药卫生—中药学]