EB病毒相关B细胞淋巴瘤的研究进展:分子机制与靶向治疗策略  

Advancements in Epstein-Barr virus-associated B-cell lymphomas:molecular mechanisms and targeted therapeutic strategies

作　　者：李艺祺 贝锦新[1] LI Yi-Qi;BEI Jin-Xin(State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室,广东省鼻咽癌诊治研究重点实验室,广东省恶性肿瘤临床医学研究中心,中山大学肿瘤防治中心,广州510060

出　　处：《中国科学：生命科学》2024年第12期2344-2356,共13页Scientia Sinica(Vitae)

基　　金：国家自然科学基金国际(地区)合作与交流项目(批准号:82261160657)资助。

摘　　要：EB病毒通过感染B淋巴细胞,在多种B细胞淋巴瘤的发生和发展中发挥重要作用.围绕EB病毒的研究不仅能够显著提升对B细胞淋巴瘤的临床诊断与疾病监测水平,还为阐明其致病机制以及开发精准高效的治疗策略提供关键线索.本文综述了三类常见的EB病毒相关B细胞淋巴瘤——伯基特淋巴瘤(Burkitt lymphoma)、霍奇金淋巴瘤(Hodgkin lymphoma)和弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma)的研究进展,重点总结了病毒感染在B细胞淋巴瘤发生和发展中的分子机制,并系统探讨了靶向EB病毒的治疗策略及其应用前景,为推动相关疾病的精准医学研究和临床转化提供了重要理论依据和实践指导.Epstein-Barr virus(EBV)plays a critical role in the initiation and progression of various types of B-cell lymphomas through its infection of B lymphocytes.Research on EBV not only significantly enhances the clinical diagnosis and disease monitoring of B-cell lymphomas but also provides key insights into its pathogenic mechanisms and the development of precise and effective therapeutic strategies.This review summarizes recent advancements in the study of three common EBV-associated B-cell lymphomas:Burkitt lymphoma(BL),Hodgkin lymphoma(HL),and diffuse large B-cell lymphoma(DLBCL).It focuses on the molecular mechanisms underlying EBV infection in the pathogenesis of B-cell lymphomas and systematically discusses EBV-targeted therapeutic strategies and their clinical potential.These findings provide valuable theoretical foundations and practical guidance for advancing precision medicine research and clinical translation in EBV-associated diseases.

关 键 词：EB病毒 B细胞淋巴瘤 临床表现 致病机制 靶向治疗策略 

分 类 号：R733.1[医药卫生—肿瘤]