乳酸菌调控宿主脂肪代谢的研究进展  

Advances in the regulation of host fat metabolism by Lactobacillus

作　　者：陈忠 马杰[1] 夏嗣廷 陈清华[1] 尹杰[1] 陈家顺[1] CHEN Zhong;MA Jie;XIA SiTing;CHEN QingHua;Yin Jie;CHEN JiaShun(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China)

机构地区：[1]湖南农业大学动物科学技术学院,长沙410128

出　　处：《中国科学：生命科学》2024年第12期2427-2437,共11页Scientia Sinica(Vitae)

摘　　要：脂肪代谢紊乱是代谢综合征的主要诱发因素之一.在脂肪代谢紊乱的动物模型或临床肥胖人群中,肠道微生物,尤其是乳酸菌属的多样性和组成发生显著性变化.乳酸菌作为一种常见的益生菌,也被广泛报道能够影响到宿主脂肪代谢.基于此,本文探讨乳酸菌与脂肪代谢的关系,分析其代谢产物短链脂肪酸、胆汁酸、胞外多糖和亚油酸调控脂肪代谢的潜在分子机制,并阐述同属乳酸菌和不同复合乳酸菌之间的作用差异,以期明确乳酸菌调控宿主脂肪代谢的机制,旨在为食源性途径干预脂肪代谢紊乱所引起的代谢性疾病研究提供思路和借鉴.Lipid metabolism disorder is one of the main factors causing metabolic syndrome.In animal models displaying disrupted fat metabolism or in clinical populations affected by obesity,there are substantial changes in the diversity and composition of gut microbiota,particularly within the genus Lactobacillus.As a probiotic,Lactobacillus is expected to extensively impact host fat metabolism.Therefore,this study explored the relationship between Lactobacillus and fat metabolism.It analyzed the underlying molecular mechanisms by which metabolites of Lactobacillus(such as short-chain fatty acids,bile acids,exopolysaccharides,and linoleic acid)regulate fat metabolism.Additionally,the study elaborated on the differences between the same and different Lactobacillus complexes to clarify the mechanism of lactic acid bacteria in regulating host fat metabolism.This study aims to provide perspectives and references for controlling food-borne metabolic diseases caused by lipid metabolism disorders.

关 键 词：乳酸菌 脂肪代谢 代谢产物 

分 类 号：S852.6[农业科学—基础兽医学]