孤独症谱系障碍的神经影像学特征与遗传机制:多模态数据整合的现状与展望  

Neuroimaging characteristics and genetic mechanisms of autism spectrum disorder:The current status and prospects of multimodal data integration

作　　者：罗丹 赵纯风 刘衡 LUO Dan;ZHAO Chunfeng;LIU Heng(Department of Radiology,Affiliated Hospital of Zunyi Medical University,Engineering Research Center of Intelligent Medical Imaging in Guizhou Higher Education Institutions,Medical Imaging Center of Guizhou Province,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院放射科,贵州省高等学校智能医学影像工程研究中心,贵州省医学影像中心,遵义563000

出　　处：《磁共振成像》2024年第12期160-164,170,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金地区科学基金项目(编号:82360340);贵州省优秀青年科技人才项目(编号:黔科合平台人才[2021]5620);遵义市科技创新人才团队项目(编号:遵市科人才[2024]5号);遵义医科大学未来临床名医人才计划项目(编号:rc220211205);遵义医科大学附属医院优秀青年人才培养计划项目(编号:rcz20240418)。

摘　　要：孤独症谱系障碍(autism spectrum disorder,ASD)是一种复杂的神经发育障碍,其病理机制涉及神经影像学异常与遗传因素的交互作用。本文综述了ASD的神经影像学特征及遗传变异对脑结构与功能的特异性影响,探讨了神经影像与遗传学数据整合在解析ASD病理机制中的重要作用,同时指出了现有研究局限并提出未来展望,以期为ASD的精准诊断与个性化干预提供新的方向。Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder,the pathological mechanism of which involves the interaction between neuroimaging abnormalities and genetic factors.This paper reviews the neuroimaging characteristics of ASD and the specific effects of genetic variations on brain structure and function,exploring the important role of integrating neuroimaging and genetic data in deciphering the pathological mechanisms of ASD.It also points out the limitations of existing research and proposes future prospects,aiming to provide new directions for the precise diagnosis and personalized intervention of ASD.

关 键 词：孤独症谱系障碍 神经影像学 磁共振成像 多模态影像 遗传学 

分 类 号：R445.2[医药卫生—影像医学与核医学] R748[医药卫生—诊断学]