奥美拉唑联合生长抑素在急性上消化道出血治疗中的应用  

Application of Omeprazole Combined with Somatostatin in the Treatment of Acute Upper Gastrointestinal Bleeding

作　　者：宋泽红 SONG Zehong(Department of Spleen and Stomach Diseases,Kaiyang Hospital of Integrated Traditional Chinese and Western Medicine,Guiyang 550300,China)

机构地区：[1]开阳县中西医结合医院脾胃病科,贵州贵阳550300

出　　处：《中华灾害救援医学》2024年第11期1350-1353,共4页Chinese Journal of Disaster Medicine

摘　　要：目的探讨急性上消化道出血采取生长抑素联合奥美拉唑治疗的临床效果。方法回顾性分析2020年1月至2024年6月开阳县中西医结合医院救治的98例急性上消化道出血患者的临床资料。根据治疗药物的不同分为研究组(给予奥美拉唑+生长抑素进行治疗)和对照组(给予生长抑素进行治疗),每组各49例。比较两组患者的临床止血效果和相关指标,以及凝血、氧化应激、炎症相关指标,不良反应发生情况。结果治疗后,研究组临床止血总有效率显著高于对照组(P<0.05)。与对照组患者相比,研究组患者的输血量更少(P<0.001),且止血时间和住院时间更短,差异有统计学意义(P<0.001)。两组患者治疗后,凝血酶原时间、部分凝血活酶时间、凝血酶时间均显著升高(P<0.05);纤维蛋白原水平显著降低(P<0.001);且与对照组患者相比,研究组各项指标更优(P<0.05)。经治疗后,两组患者皮质醇、抗利尿激素、去甲肾上腺素水平均降低(P<0.001);且与对照组患者相比,研究组患者各项指标降低更显著(P<0.001)。在治疗后,两组患者降钙素原、超敏C反应蛋白、肿瘤坏死因子-α水平均降低(P<0.001);且与对照组患者相比,研究组患者降钙素原、超敏C反应蛋白、肿瘤坏死因子-α水平降低更显著(P<0.001)。治疗后,研究组不良反应的总发生率与对照组相比无显著差异(P>0.316)。结论生长抑素与奥美拉唑联合应用,可抑制急性上消化道出血患者机体内炎症反应,减轻应激反应,快速止血,缩短住院时间,且临床疗效显著,安全性较高。Objective This study aims to investigate the efficacy of combined somatostatin and omeprazole treatment in patients with acute upper gastrointestinal bleeding.Methods A retrospective analysis was conducted on the clinical data of 98 patients diagnosed with acute upper gastrointestinal bleeding and treated at the Integrated Traditional and Western Medicine Hospital in Kaiyang County from January 2020 to June 2024.Patients were divided into two groups based on their treatment regimen:the study group(n=49)received omeprazole combined with somatostatin,while the control group(n=49)received somatostatin alone.The clinical hemostatic efficacy and associated indicators,including coagulation,oxidative stress,and inflammation-related markers,as well as the incidence of adverse reactions,were compared between the two groups.Results Following treatment,the overall clinical hemostatic efficacy in the study group was significantly higher than that in the control group(P<0.05).Patients in the study group required significantly less blood transfusion compared to those in the control group(P<0.001),and they experienced shorter hemostatic and hospital stay durations,with significant differences observed(P<0.001).After treatment,prothrombin time,activated partial thromboplastin time,and thrombin time were significantly prolonged in both groups(P<0.05),while fibrinogen levels significantly decreased(P<0.001).The study group showed superior outcomes in these indicators compared to the control group(P<0.05).Post-treatment,levels of cortisol,antidiuretic hormone,and norepinephrine decreased in both groups(P<0.001),with the study group exhibiting more pronounced reductions(P<0.001).Additionally,levels of procalcitonin,high-sensitivity C-reactive protein,and tumor necrosis factor-αdecreased significantly in both groups(P<0.001),with the study group showing significantly greater reductions compared to the control group(P<0.001).The overall incidence of adverse reactions in the study group did not differ significantly from that in the co

关 键 词：生长抑素 奥美拉唑 胃肠出血 应激障碍 创伤性 

分 类 号：R573.2[医药卫生—消化系统]