腹部CT联合血清IMA、VEGF对缺血性结肠炎的早期诊断价值  

Early Diagnostic Value of Abdominal CT Combined with Serum IMA and VEGF in Ischemic Colitis

作　　者：赵卫东 王毅刚 李明珠 史宏伟 李华 ZHAO Wei-dong;WANG Yi-gang;LI Ming-zhu;SHI Hong-wei;LI Hua(Department of Medical Imaging,Tangshan Central Hospital,Tangshan 063000,Hebei Province,China;Department of Anorectal Surgery,Tangshan Central Hospital,Tangshan 063000,Hebei Province,China)

机构地区：[1]唐山中心医院医学影像科,河北唐山063000 [2]唐山中心医院肛肠外科,河北唐山063000

出　　处：《中国CT和MRI杂志》2025年第1期156-158,共3页Chinese Journal of CT and MRI

基　　金：河北省医学科学研究课题计划(20231840)。

摘　　要：目的 探究腹部CT联合血清IMA、VEGF对缺血性结肠炎的早期诊断价值。方法 研究对象选择2020年5月至2022年5月在本院就诊的76例疑似IC患者,根据结肠镜诊断分为IC组和非IC组,所有入选者均进行腹部CT检查,检测血清IMA、VEGF水平。结果 IC组和非IC组腹痛和便血发生率比较有差异(P<0.05)。IC组腹部CT(异常)、肠壁水肿增厚和肠腔周围絮状影发生率高于非IC组(P<0.50)。IC组血清IMA、VEGF水平显著高于非IC组(P<0.05)。根据ROC曲线得知,血清IMA诊断IC的AUC为0.892,血清VEGF诊断IC的AUC为0.855,二者联合诊断IC的AUC阿为0,967。腹部CT在IC诊断中准确度为88.16%;IMA在IC诊断中准确度为82.89%;VEGF在I C诊断中准确度为80.26%;三者联合检测在IC诊断中准确度为92.11%。结论 IMA、VEGF在IC患者血清中表达显著升高,腹部CT联合血清IMA、VEGF可提高对IC的早期诊断价值。Objective To explore the early diagnostic value of abdominal computed tomography(CT)combined with serum ischemic modified albumin(IMA)and vascular endothelial growth factor(VEGF)in ischemic colitis(IC).Methods From May 2020 to May 2022,76 suspected IC patients who visited our hospital were collected and grouped into IC group and non IC group based on colonoscopy diagnosis;all selected candidates underwent abdominal CT examination;enzyme linked immunosorbent assay(ELISA)was applied to detect serum IMA and VEGF;ROC curve was plotted to analyze the critical diagnostic points of serum IMA and VEGF for IC;four grid table was applied to analyze the diagnostic value of abdominal CT combined with serum IMA and VEGF for IC.Results There was a difference in the incidences of abdominal pain and rectal bleeding between the IC group and the non IC group(P<0.05).The incidences of abdominal CT(abnormal),intestinal wall edema and thickening,and flocculent shadows around the intestinal cavity in the IC group were higher than those in the non IC group(P<0.05).The serum levels of IMA and VEGF in the IC group were obviously higher than those in the non IC group(P<0.05).According to the ROC curve,the AUC for serum IMA diagnosis of IC was0.892,and the AUC for serum VEGF diagnosis of IC was 0.855,The AUC of the combined diagnosis of IC was 0.967,the accu racy of abdominal CT in IC diagnosis was 88.16%;the accu racy of IMA in IC diagnosis was 82.89%;the accuracy of VEGF in IC diagnosis was 80.26%;the accuracy of the three combined tests in IC diagnosis was 92.11%.Conclusion The expression of IMA and VEGF in the serum of IC patients is obviously increased.Abdominal CT combined with serum IMA and VEGF can improve the early diagnostic value of IC.

关 键 词：计算机断层扫描 缺血修饰白蛋白 血管内皮生长因子 缺血性结肠炎 诊断 

分 类 号：R574.62[医药卫生—消化系统]