神经母细胞瘤分子影像和放射性核素治疗现状  

Current status of molecular imaging and radionuclide therapy of neuroblastoma

作　　者：李司琪 杨吉刚[1] LI Siqi;YANG Jigang(Department of Nuclear Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院核医学科,北京100050

出　　处：《中国医学影像技术》2024年第12期1809-1812,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(82272034);北京市自然科学基金(7232031);北京市西城区科技专项(XCSTS-TI2024-06)。

摘　　要：神经母细胞瘤(NB)是儿童最常见的颅外实体肿瘤,发病率、复发率及死亡率均较高。核医学对于诊断及治疗NB至关重要。基于PET和SPECT的核医学分子影像可在分子层面为早期诊断、治疗NB及评估疗效等提供依据;基于放射性核素的靶向治疗可抑制或杀伤NB细胞而改善预后。本文就NB分子影像和放射性核素治疗现状进行述评。Neuroblastoma(NB)is the most common extracranial solid tumor in children,with high incidence rate,recurrence rate and mortality.Nuclear medicine plays a crucial role in diagnosis and treatment of NB.Nuclear medicine molecular imaging based on PET and SPECT can provide molecular basis for early diagnosis,treatment and therapeutic effective evaluation of NB.Targeted therapy based on radionuclide can inhibit or kill NB cells and improve the prognosis.The current status of molecular imaging and radionuclide therapy of NB were reviewed in this article.

关 键 词：儿童 神经母细胞瘤 正电子发射断层显像 体层摄影术 发射型计算机 单光子 放射性同位素 

分 类 号：R739.4[医药卫生—肿瘤] R817[医药卫生—临床医学]