VEGF在脑出血中的调控机制及治疗作用  

Regulatory role and therapeutic effects of VEGF in intracerebral hemorrhage

作　　者：李晶怡 丛婧 霍宏[2] 张莹(综述)[2] 王东岩(审校)[2] LI Jingyi;CONG Jing;HUO Hong(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出　　处：《中风与神经疾病杂志》2024年第12期1142-1147,共6页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金面上项目(82374601);黑龙江中医药管理局青年中医药科研课题(ZHY2024-229);黑龙江中医药大学创新团队建设项目(2017sit01)。

摘　　要：脑出血发生后,颅内血管破裂导致颅内压增高,脑血流量和灌注压降低。这些变化直接影响了的血管内氧气的供应,引发一系列难以恢复的脑损伤。血管生成已被证明可以改善脑出血的预后。血管内皮生长因子(VEGF)被认为是血管生成和血管形成的主要调节因子,可通过多途径参与脑出血病理过程的调控。它不但可以促进血管新生,介导新血管形成,改善脑出血区的氧气和营养供应,还可以减弱炎症反应、抑制细胞凋亡、上调营养因子、下调毒性蛋白,保护神经细胞。本研究旨在VEGF在脑出血病理过程中的调控机制以及VEGF在脑出血治疗中的作用进行了探讨。In intracranial hemorrhage,the rupture of intracranial blood vessels results in elevated intracranial pressure and reduced cerebral blood flow and perfusion pressure,which directly impact blood oxygen supply to cause a series of brain injuries that are hard to recover.Angiogenesis has been demonstrated favorable for the prognosis of cerebral hemorrhage.Vascular endothelial growth factor(VEGF)is regarded as a main regulator of angiogenesis and vasculogenesis,which can regulate the pathological mechanism of cerebral hemorrhage through multiple pathways.It can not only facilitate and mediate the formation of new blood vessels to enhance oxygen and nutrient supply in bleeding areas,but also protect neural cells through alleviating inflammation,inhibiting cell apoptosis,up-regulating trophic factors,and down-regulating toxic proteins.This review focuses on the regulatory role of VEGF in the pathological process of cerebral hemorrhage as well as its effects in the treatment of cerebral hemorrhage.

关 键 词：脑出血 血管内皮再生因子 血管再生 神经保护 治疗 

分 类 号：R743.34[医药卫生—神经病学与精神病学]