人参三醇组甙抗辐射作用的研究  

Study on Antiradiation Effect of Panaxatriol

作　　者：李校坤[1] 林灼锋[1] 黄亚东[1] 邓青[1] 许华[1] 

机构地区：[1]暨南大学医药生物技术研究开发中心,广州510632

出　　处：《中药材》2002年第11期805-808,共4页Journal of Chinese Medicinal Materials

基　　金：广东省自然科学重点基金(编号:C010502)

摘　　要：目的:探讨人参三醇组甙(panaxatriol)的辐射防护作用,为开发相关的护肤产品提供实验依据。方法:小鼠接受X射线照射前用人参三醇组甙灌胃,照射后3h取小鼠骨髓细胞制备染色体标本,观察骨髓细胞染色单体型和染色体型畸变以及畸变细胞数。结果:辐照前给予人参二醇组甙200～400 mg/kg可降低辐射诱发染色体和细胞的畸变;给药剂量和给药时间与防护效应呈正相关,照射剂量与防护效应呈负相关。结论:人参三醇组甙对骨髓细胞染色体具有较好的辐射防护作用。Objective: To study antiradiation effect of panaxatriol (PT) and to provide an experiment basis for developing relative radiation-resistant skin care products. Methods: Mice were treated with PT or normal saline (the control group) before X-ray irradiation and were killed 3 hours after irradiation. The chromosome samples of bone marrow cells were prepared to observe the number of chromosme aberrations and chromalid mutation as well as aberrant cells. Results: PT can reduce the frequency of chromatid mutative induced by X-ray. Antiradiation effect was positively correlated with the dose of Pf and the duration of drug, and negatively correlated with the dose of X-rays. Conclusion: IT has significant antiradiation effect.

关 键 词：人参三醇组甙 染色体畸变 辐射防护 

分 类 号：R285.5[医药卫生—中药学] R14[医药卫生—中医学]