南瓜提取物对小鼠铅诱导的脂质过氧化及抗氧化酶活力的影响  

The effect of Lycopene on antioxidative enzyme in mice induced by Pb

作　　者：潘洪志[1] 郭守利[2] 

机构地区：[1]哈尔滨医科大学公共卫生学院 [2]哈尔滨医科大学附属二院动物实验中心

出　　处：《齐齐哈尔医学院学报》2002年第10期1081-1082,共2页Journal of Qiqihar Medical University

摘　　要：目的　观察染铅小鼠抗氧化系统的改变及南瓜提取物 (PumpkinDistillableSubject,PKD)对抗氧化酶系统的影响。方法　小鼠经饮水铅染毒 (醋酸铅 )造成铅中毒模型后给予南瓜提取物 ,4周后处死 ,测定血清和肝匀浆的超氧化物歧化酶 (SOD)活性、谷胱甘肽过氧化物酶 (GSH -Px)活力、丙二醛(MDA)含量。结果　给予南瓜多糖的小鼠血清和肝组织的SOD活性、GSH -Px活力上升 ,MDA含量降低 ,与中毒模型组相比 ,差异有显著性。结论　铅中毒可引起小鼠过氧化损伤 ,南瓜多糖可以减轻铅中毒引起的脂质过氧化 。Objective To observe the effect of Pumpkin Distillable Subject(PKD)on antioxidation in mice induced by Pb. Methods The mice were given Pb and PKD. After 4 weeks the activity of SOD , MDA and GSH-Px in serum and liver were measured respectively. Results Compared with Pb group,statistically the activities of SOD and GSH-Px in PKD group were increased and the concentrations of MDA were decreased significantly(P<0.05). Conclusions PKD could increase antioxidative effect and reduce lipid peroxidation induced by Pb in mice.

关 键 词：南瓜提取物 抗氧化 铅 脂质过氧化 PKD 动物模型 重金属中毒 

分 类 号：R259.952[医药卫生—中西医结合] R28[医药卫生—中医内科学]