大肠癌TGF-β1表达及与肿瘤血管生成的关系  

The expression of transforming growth factor-β1 and the correlation with the angiogenesis in colorectal carcinoma

作　　者：唐华[1] 张才全[1] 向征[1] 

机构地区：[1]重庆医科大学临床学院普外科,400016

出　　处：《肿瘤防治研究》2002年第6期468-470,共3页Cancer Research on Prevention and Treatment

摘　　要：目的　研究大肠癌组织转化生长因子 β1(TGF β1)表达和意义及在血管生成中的作用。 方法　运用免疫组化S P法检测 70例大肠癌、10例正常大肠粘膜组织标本TGF β1、血管内皮生长因子 (VEGF)表达及微血管密度 (MVD)。结果　大肠癌TGF β1表达较正常大肠粘膜明显增强 ;TGF β1过度表达与淋巴结转移、Dukes分期及预后密切相关 ;TGF β1表达与VEGF表达密切相关 ,与MVD无直接关系。 结论　TGF β1促进大肠癌细胞浸润转移 ;TGF β1过度表达可作为判断大肠癌预后具有参考意义新指标 ;TGFObjective To investigate the expression of transforming growth factor\|β1(TFG\|β1) and its significance as well as its effect on the angiogenesis in colorectal carcinoma (CRC).Methods The expression of TGF\|β1,the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in 70 patients with CRC and 10 normal colorectal mucosal tissues were examined by immunohistochemistry.Results Compared with the normal colorectal mucosal tissues,the expression of TGF\|β1 in CRC is higher.The overexpression of TGF\|β1 is associated with lymphatic metastasis,Dukes staging and poor prognosis.The expression of TGF\|β1 is closely associated with VEGF expression other than MVD.Conclusion TGF\|β1 stimulates CRC cells infiltration and metastasis.The overexpression of TGF\|β1 is a new maker can predict prognosis in patients with CRC.TGF\|β1 promotes angiogenesis indirectly through an up\|regulation of VEGF expression in CRC.

关 键 词：TGF-Β1 大肠癌 转化生长因子Β1 血管生成 免疫组化 

分 类 号：R735.34[医药卫生—肿瘤]