不同模拟体系中草酸钙结晶的比较研究  

Comparative Investigation of Crystallization of Calcium Oxalate in Different Mimetic Systems

作　　者：欧阳健明[1] 姚秀琼[1] 钟玖平[1] 谢瑜珊[1] 白钰[1] 邝荔[1] 唐雯霞[2] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,广州510632 [2]南京大学配位化学国家重点实验室,南京210093

出　　处：《高等学校化学学报》2002年第12期2237-2239,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金重点项目 (批准号 :2 0 0 310 10 );教育部重点科学技术项目 (批准号:1998-12 1);广东省自然科学基金;南京大学配位化学国家重点实验室开放基金资助

摘　　要：The nucleation, growth and aggregation of calcium oxalate(CaC 2O 4) crystals were comparatively investigated in five different mimetic systems: water, NaCl solution, artificial urine, healthy urine and lithogenic urine by using scanning electron microscopy(SEM). The effects of original concentration of calcium ion and oxalate ion and crystallization time on the morphology, density and the size of CaC 2O 4 crystals were discussed. In lithogenic urine, calcium oxalate monohydrate(COM) crystals were the dominant phase. However, a mixture of COM and calcium oxalate dihydrate(COD) with a molar ratio of about 3∶2 was obtained in the healthy urine. COD has a less affinity for renal tubule cell surface, so COD is easy to be expelled out from body and there is a less probability of stone-forming in the healthy urine. The fastest nucleation and growth of CaC 2O 4 crystals were obtained in water and NaCl solution, respectively. The size of CaC 2O 4 crystals decreases in the following order: NaCl solution>artificial urine>lithogenic urine>healthy urine>water.The nucleation, growth and aggregation of calcium oxalate(CaC 2O 4) crystals were comparatively investigated in five different mimetic systems: water, NaCl solution, artificial urine, healthy urine and lithogenic urine by using scanning electron microscopy(SEM). The effects of original concentration of calcium ion and oxalate ion and crystallization time on the morphology, density and the size of CaC 2O 4 crystals were discussed. In lithogenic urine, calcium oxalate monohydrate(COM) crystals were the dominant phase. However, a mixture of COM and calcium oxalate dihydrate(COD) with a molar ratio of about 3∶2 was obtained in the healthy urine. COD has a less affinity for renal tubule cell surface, so COD is easy to be expelled out from body and there is a less probability of stone-forming in the healthy urine. The fastest nucleation and growth of CaC 2O 4 crystals were obtained in water and NaCl solution, respectively. The size of CaC 2O 4 crystals decreases in the following order: NaCl solution>artificial urine>lithogenic urine>healthy urine>water.

关 键 词：模拟体系 结晶 草酸钙 扫描电子显微镜 生物矿化 泌尿系结石 体外模拟 

分 类 号：R691.4[医药卫生—泌尿科学]