广州地区献血者中输血传播病毒感染情况调查  

作　　者：郑优荣[1] 肖韶英[1] 肖昕[2] 李玉笑[1] 何珠[1] 李少华[1] 

机构地区：[1]广州血液中心,510095 [2]暨南大学医学院,510630

出　　处：《广州医药》2002年第6期62-63,共2页Guangzhou Medical Journal

摘　　要：目的 :了解广州地区献血人群中的输血传播病毒 (TTV)感染状况 ,探讨TTV与丙氨酸氨基转移酶(ALT)、HBsAg及抗HCV指标的相关性。方法 :用聚合酶链反应 (PCR)方法对不同献血人群血清标本进行TTV DNA检测 ,并对所有标本进行了ALT、HBsAg、抗 HCV、抗 HIV、梅毒及抗 HAV、抗 HEV、抗 HGV筛查。结果 :献血者中的TTV DNA阳性率为 7 6 % (43/ 5 6 4 ) ,其中有偿献血者和无偿献血者中的TTV DNA阳性率分别为 9 4 %、 5 9% ;单一ALT异常无偿献血者的TTV DNA阳性率明显高于ALT正常无偿献血者 (10 6 %、 4 2 % ,P <0 0 5 ) ,HBsAg及抗 HCV阳性献血者中的TTV DNA阳性率分别为 11 1%、 8 3%。结论 :本文结果显示广州地区献血者中存在TTV感染 ,而且在有偿献血者中感染率相对较高。TTV可以单独感染也可与HBV、HCV重叠感染并与ALT密切相关。Objective: To investigate the molecular epidemiology of transfusion transmitted virus (TTV) infection and its distribution in different blood donors in Guangzhou and to study the relation of TTV to ALT,HBsAg and Anti HCV Methods: TTV DNA in serum samples was detected by polymerase chain reaction Detection of ALT,HBsAg,Anti HCV,Anti HIV?Syphilis,Anti HAV,Anti HEV,Anti HGV of these serum samples were also carried out Results: The positive rate of TTV DNA of the blood donors was 7 6%(43/564),the positive rate of TTV DNA of voluntary blood donors,professional blood donors were 5 9% (17/289),9 4% (26/275) respectively The positive rate of TTV DNA in donors with ALT abnormal was higher than in donors with ALT normal Conclusion: This study proved that TTV infection existed in Guangzhou,TTV might infect blood donors alone or co infected with hepatitis B and C virus,and was hightly relative to ALT There was high rate of TTV infection in professional blood donors

关 键 词：广州市 输血传播病毒感染 输血传播病毒 献血者 聚合酶链反应 疾病调查 

分 类 号：R181.3[医药卫生—流行病学]