nm23H1、E-Cadherin和CD44基因产物在卵巢浆液性囊腺癌中的表达  

The Expression of nm23Hl ,E - Cadherin and CD44 gene in Serous Cystadeno - carcinoma of Overy

作　　者：施公胜[1] 谢阳桂[2] 孙超[1] 

机构地区：[1]南通医学院附属医院病理科 [2]南通医学院影像科,南通226001

出　　处：《中国临床医学》2002年第5期477-479,共3页Chinese Journal of Clinical Medicine

基　　金：南通市科委科研基金(编号:S9623)

摘　　要：目的:探讨肿瘤转移抑制基因nm23H1和黏附分子E-Cadherin以及CD44在卵巢浆液性囊腺癌中的表达,以及这种表达与临床指标、生物学行为之间的关系。方法:用免疫组化S-P法检测nm23H1、E-Cadherin和CD44基因蛋白在肿瘤组织中的表达。结果:肿瘤原发灶和相应淋巴结中,nm23H1、E-Cadherin和CD44蛋白表达与淋巴结转移、临床分期、组织学分期有一定关系。结论:nm23H1、E-Cadherin和CD44基因在卵巢浆液性囊腺癌的发展转移中起重要作用,对这三种基因的共同检测具有一定临床价值。Objective: To study the expression of nm23Hl, E - Cadherin and CD44 gene in serous cystadenocarcinoma of o-vary ,and the relationship between expression and clinical, biological behaviour. Methods: To detect the protein expression of nm23H1, E-Cadherin and CD44 gene in tumor tissue with S-P method of immunohistochemistry. Results: The protein expression of nm23H1, E - Cadherin and CD44 gene in primary focus and metastasized lymph node showed that the expression had some relationship with tumor's lymphoid metastasis, clinical stage and histological stage. Conclusion: The protein expression of nm23H1, E - Cadherin and CD44 gene may play an important role in the metastasis of ovary serous cystadenocarcinoma. The examination of these three protein is valuable in clinical work.

关 键 词：NM23H1 E-CADHERIN CD44 免疫组化 卵巢浆液性囊腺癌 卵巢肿瘤 基因表达 

分 类 号：R737.31[医药卫生—肿瘤]