MMP-2在肺癌中的表达  

Expression of Matrix Metalloproteinase - 2 in Lung Cancer

作　　者：孙书明[1] 罗金芳[2] 桂律[2] 胡志雄[1] 金盈[1] 金复生[3] 

机构地区：[1]复旦大学附属金山医院肺科 [2]复旦大学附属金山医院病理科 [3]复旦大学附属金山医院职防科,上海200540

出　　处：《中国临床医学》2002年第5期490-492,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:研究肺癌和正常肺组织中基质金属蛋白酶2(MMP-2)的表达。方法:采用免疫组织化学EnVision方法,对71例肺癌标本和31例正常肺组织检测MMP-2的表达。结果:在71例肺癌标本中,小细胞肺癌只有4例,MMP-2表达阳性者占3例(75.0％);非小细胞肺癌(NSCLC)有67例,年龄40岁以上者64例,MMP-2表达阳性者占39例,阳性率60.9％(39/64)。正常肺标本31例,年龄40岁以下者MMP-2表达均为阴性,年龄在40岁以上者26例,MMP-2阳性表达9例,阳性率34.6％(9/26),40岁以上NSCLC标本的MMP-2阳性表达与正常肺标本比较差异具有统计学意义(P<0.05)。结论:在NSCLC中高表达的MMP-2是肺癌的一种好的肿瘤标记物。Objective: To study the expression of matrix metalloproteinase - 2 in lung cancer. Methods: En Vision immuno-histochemical technique was used to detect the expression of matrix metalloproteinase - 2 in 71 cases of lung cancer and 31 cases of normal lung tissue. Results:In 71 patients, 4 cases of which were small -cell lung cancer only, and MMP -2 immunoreactivity was demonstrated in 3(75.0%). 67 cases were non - small - cell lung cancer(NSCLC), 64 cases of which were over 40 years, MMP - 2 immunoreactivity was demonstrated in 39(60.9% ). There were normal lung specimen, MMP - 2 immunoreactivity was all negative in cases of below 40 years, MMP - 2 immunoreactivity of 26 cases of over 40 years was demonstrated in 9(34. 6%). There was significant difference between the expression of MMP - 2 in NSCLC and normal lung specimen. Conclusion:High expression of MMP -2 in NSCLC was a good tumor marker.

关 键 词：基质金属蛋白酶2 小细胞肺癌 非小细胞肺癌 免疫组织化学 基因表达 

分 类 号：R734.2[医药卫生—肿瘤]