内镜下注射肉毒毒素治疗贲门失弛缓症的研究  

The study of intrasphincteric injection of botulinum toxin in patients with achalasia

作　　者：杨崇美[1] 刘吉勇[1] 刘清英[1] 张安忠[1] 许洪伟[1] 王洪波[1] 

机构地区：[1]山东省立医院,山东济南250021

出　　处：《山东医药》2002年第22期1-2,共2页Shandong Medical Journal

摘　　要：将 4 8例贲门失弛缓症患者随机分为两组 ,A组注射肉毒毒素治疗 ,B组用小气囊扩张治疗。分别于治疗后 1周、 3个月和 1年比较两组患者的临床症状积分、下食管括约肌的压力 (L ESP)、松弛率 (L ESRR)。结果 :治疗后 1周、 3个月和 1年的有效率及治疗前后 L ESP、L ESRR的差值 ,注射肉毒毒素组均高于小气囊扩张组 ;两组均无并发症发生。认为内镜下食管下括约肌内注射肉毒毒素治疗贲门失弛缓症的近期疗效高 ,且患者痛苦小。patients with achalasia were divided randomly into two groups:group A were treated with intrasphincteric botulinum toxin(BT)and group B were treated with small balloon dilation The clinic scores,low oesophageal sphincteric pressure(LESP),low oesophageal sphincteric relax rate(LESRR) of two groups were compared with at 1st week,3rd month and 1st year after treating respectively The effective rates and gaps of LESP and LESRR between pre treatment and post treatment were higher in group A at 1st week,3rd month and 1st year,and there was not any complication in two groups This suggests that the method of intrasphincteric injection of botulinum toxin is effective,with lower complications and lighter chest pain

关 键 词：内镜下注射 肉毒毒素 治疗 贲门失弛缓症 气囊扩张 近期疗效 

分 类 号：R573.7[医药卫生—消化系统]