沙丁胺醇在乙基化β-环糊精溶液中的包合作用  

The Inclusion Action of Salbutamol in Ethylated β-Cyclodextrin Solution

作　　者：冯波[1] 张振家[1] 何仲贵[2] 李砥晖[1] 张文希[1] 

机构地区：[1]第四军医大学吉林军医学院,132013 [2]沈阳药科大学药学院,110016

出　　处：《医药导报》2002年第12期807-808,共2页Herald of Medicine

摘　　要：目的 :测定沙丁胺醇在不同浓度乙基化 β 环糊精溶液中的溶解度曲线 ,以及包合物的组成摩尔比和稳定性常数。方法 :通过连续递变实验确定包合物的组成摩尔比 ,并根据紫外增量法测定包合物的稳定性常数。结果 :沙丁胺醇与乙基化 β 环糊精包合物的组成摩尔比为 1∶1,包合物的稳定性常数为 45 64L·mol 1,沙丁胺醇溶解度随乙基化 β 环糊精浓度的增大而减小。结论 :沙丁胺醇与乙基化 β 环糊精可形成较稳定的 1∶1包合物。Objective:To plot the solubility curve of salbutamol (SAL) in ethylated β cyclodextrin (ECD) solution of and to determine the constitutive molar ratio of salbutamol ethylated β cyclodextrin (SAL ECD) inclusion compound and its stability constant. Method:The constitutive molar ratio of SAL ECD inclusion compound was determined by continuous variation plotting while its stability constant was determined by measuring absorbance. Results:The constitutive molar ratio of SAL to ECD inclusion compound was 1:1, and stability constant of the inclusion compound was 4 564 L·mol 1 . The solubility of SAL in ECD solution decreased with the increase of the concentration of ECD. Conclusion:A relatively stable inclusion compound of SAL and ECD (1∶1) can be formed.

关 键 词：包合作用 沙丁胺醇 乙基化β-环糊精 溶解度 组成摩尔比 稳定性 

分 类 号：R974[医药卫生—药品] R927.1[医药卫生—药学]