海洛因依赖与儿茶酚胺氧位甲基转移酶基因-287 A/G多态性的关联研究  

Association study of heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase gene

作　　者：曹莉萍[1] 李涛 许珂[3] 刘协和[1] 

机构地区：[1]四川大学华西医院心理卫生研究所 [2]DepartmentofPsychologicalMedicine [3]广州市脑科医院

出　　处：《中华医学遗传学杂志》2002年第6期499-501,共3页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金 (398762 58) ;博士点基金 (9957)~~

摘　　要：目的　探讨海洛因依赖和儿茶酚胺氧位甲基转移酶 (catechol- O- methyltransferase,COMT)基因 - 2 87A/ G多态性的关系。方法　采用 PCR技术 ,检测了 2 6 8例海洛因依赖者和 177名正常对照的COMT基因 - 2 87A/ G多态性。结果　海洛因依赖者 COMT基因 - 2 87A/ G多态的基因型 AA的频率显著高于对照组 (χ2 =7.41,P=0 .0 2 5 ) ,等位基因 A的频率也显著高于对照组 (χ2 =5 .6 9,P=0 .0 17)。结论提示 COMT基因 - 2 87A/ G多态性与海洛因依赖的易感性有关。Objective: To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene. Methods: Genotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls. Results: Weak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (X2 = 7. 41, P = 0. 025), and genotype AA was higher in the former. The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (X2 = 5. 69, P = 0. 017). Conclusion: The results suggested that liability to heroin-dependence was associated with -287 A/G polymorphism of COMT gene.

关 键 词：海洛因依赖 儿茶酚胺氧位甲基转移酶基因 -287A/G多态性 

分 类 号：R749.61[医药卫生—神经病学与精神病学]