抗小细胞肺癌单克隆抗体2F_7F(ab′)_2片段的肺癌放射免疫显像  

Clinical radioimmunoscintigraphic study with monoclonal antibody 2F_7F(ab′)_2 segment against small cell lung cancer

作　　者：苗积生[1] 潘惠忠[1] 刘进军[1] 吴吉勇[1] 沈毅[1] 林祥通[2] 刘永昌[2] 薛方平[2] 左传涛[2] 史德刚[2] 

机构地区：[1]上海市肺科医院核医学科,200433 [2]复旦大学附属华山医院核医学科

出　　处：《中华核医学杂志》2002年第5期288-290,共3页Chinese Journal of Nuclear Medicine

基　　金：八六三国家高科技研究发展计划基金资助项目(1 0 2 90 1 0 1 )

摘　　要：目的　探讨抗小细胞肺癌单克隆抗体99Tcm 2F7F(ab′) 2 放射免疫显像对肺癌诊断的可行性及用药安全性。方法　 1 8例肺癌患者静脉注射99Tcm 2F7F(ab′) 2 1～ 2mg约 1 1 1 0MBq ,7～ 8h后行胸部平面前后位及断层显像 ,2 4h再行平面显像。显像结果与X线胸片对照 ,以病灶区与正常对照区的计数比 (T/N) >1 .2为阳性。结果　 1 8例患者从注药到显像结束以及随后的随访均未发现任何不良反应。未经治疗或正在化疗的小细胞肺癌患者 9例显像均呈阳性 ;化疗超过 1 0d或多次化疗者计 5例 ,4例显像阳性 ,临床均为治疗效果较差者 ,余 1例显像阴性 ,治疗效果好。 2例腺癌、1例鳞癌显像阴性 ,另 1例腺癌显像阳性。 2 4hT/N比值比 7～ 8h大。结论　99Tcm 2F7F(ab′) 2 显像阳性率高 ,无不良反应。Objective To investigate the feasibility and safety of using monoclonal antibody ~ 99Tc^m-2F 7F(ab′) 2 segment against small cell lung cancer in radioimmunoscintigraphic study. Methods Eighteen lung cancer patients were included and a dosage of ~ 99Tc^m-2F 7F(ab′) 2 of 1～2 mg(1 110 MBq) was iv.injected. The anterior and posterior chest planar imaging and tomographic scan were performed after 7～8 h, the same planar scan was repeated after 24 h. The scan results were compared with the chest radiography, and the result was considered positive if the counts rate between the focus and the contrary area (T/N) on images was more than 1.2. Results During the scanning after injection and the subsequent follow-up, no side effects were found in the 18 patients. The 9 cases of small cell lung cancer that had not received any treatment or were receiving chemotherapy in the meantime showed positive results. Five patients had undergone chemotherapy for more than 10 d or several times, among them 4 cases with positive images showed poor clinical effectiveness, the remaining 1 case with negative images had a better therapeutic efficiency. Two adenocarcinoma and 1 squamous cell carcinoma patients had negative images and another adenocarcinoma patient had positive images. The T/N value after 24 h was higher than that after 7～8 h. Conclusions The radioimmunoscintigraphy with monoclonal antibody 2F 7F(ab′) 2 segment against small cell lung cancer showed highly positive results without any side effects. The result indicates that this method could be applied in clinical practice.

关 键 词：小细胞肺癌 单克隆抗体 放射免疫显像 诊断 

分 类 号：R734.2[医药卫生—肿瘤] R730.[医药卫生—临床医学]