盐酸吉西他滨治疗复发性或难治性非霍奇金淋巴瘤  

Gemcitabine in the treatment of relapsed or refractory non-Hodgkin′s lymphoma

作　　者：马树东[1] 盛信秀[1] 罗荣城[1] 李爱民[1] 

机构地区：[1]第一军医大学附属南方医院肿瘤科,广州510515

出　　处：《中华肿瘤杂志》2002年第6期619-621,共3页Chinese Journal of Oncology

摘　　要：目的　观察盐酸吉西他滨联合顺铂 (DDP)、强的松 (PDN)对复发性或难治性进展型非霍奇金淋巴瘤的疗效和毒副反应。方法　盐酸吉西他滨 10 0 0mg m2 ,d 1,d 8,静脉滴注 ;DDP 2 5mg m2 ,d1～ 3,静脉滴注 ;PDN 6 0mg m2 ,d1～ 5 ,口服。以 3～ 4周为一个化疗周期。 15例复发性或难治性进展型非霍奇金淋巴瘤患者 ,疗程不少于 3个周期。结果　 15例患者中 ,11例获得缓解 ,占 73.3%。其中完全缓解 (CR) 5例 ,部分缓解 (PR) 6例。 6例具有B类症状的患者中 ,4例症状消失 ,1例明显改善 ,1例无改善。化疗毒副作用主要为轻度的胃肠道反应 ,极少数患者出现严重的骨髓抑制。结论盐酸吉西他滨联合DDP、PDN对复发性或难治性进展型非霍奇金淋巴瘤有较好的近期疗效 ,能明显改善患者症状 ,且大部分患者可以承受其毒性 ,是一个值得进一步验证的补救性化疗方案。Objective To evaluate the efficacy and drug-related toxicity of combined gemcitabine, cisplatin, and prednisone for the treatment of patients with relapsed or refractory aggressive non-Hodgkin′s lymphoma (NHL). Methods Fifteen patients with histologically confirmed relapsed or refractory aggressive NHL were included in this study. Gemcitabine was given on D1, 8 of a three to four weeks schedule at a dose of 1 000 mg/m2 intravenously over 30 minutes for no less than three cycles, and cisplatin was given on D1-3 at a dose of 25 mg/m2. Prednisone was taken orally on D1-5 at a dose of 60 mg/m2. Results Of 15 patients, 11 patients ( 73.3%) showed responses:5 patients (33.3%) giving complete response and 6 patients (40.0%) partial response. Four patients′ symptoms disappeared, and 1 in 6 patients was alleviated of type B symptoms. Drug-related toxic effects of chemotherapy were mild gastrointestinal reactions in most patients and severe bone marrow depression in very few patients. Conclusion The present combination of gemcitabine, cisplatin, prednisone possesses moderate short-term efficacy, acceptable toxicity, and alleviation of suffering related to the disease. This protocol is worthy to be warranted as salvage for relapsed or refractory aggressive NHL.

关 键 词：非霍奇金淋巴瘤 盐酸吉西他滨 顺铂 强的松 

分 类 号：R733.1[医药卫生—肿瘤]