左旋千金藤立定碱治疗神经衰弱双盲对照研究  

A double-blind controled study L-stephoiidine therapy for treatment of neurasthenia

作　　者：毛向莹 

机构地区：[1]长垣县人民医院神经内科,河南新乡453000

出　　处：《新乡医学院学报》2002年第5期380-381,共2页Journal of Xinxiang Medical University

摘　　要：目的　探讨左旋千金藤立定碱 (SPD)治疗神经衰弱的临床疗效。方法　 14例神经衰弱患者口服SPD 50mg·d-1,与安慰剂双盲对照治疗 5周 ,以汉密顿抑郁量表 (HAMD)和精神症状自评量表 (SCL - 90 )为评定工具评判SPD临床效果。结果　SPD治疗神经衰弱有效率 ( 6 6 .7% )明显高于安慰剂组 ( 2 8.6 % ,P <0 .0 5)。有效的靶症状以头痛、失眠、记忆力减退、心烦易怒疗效显著 (P <0 .0 1) ,对多梦、注意力下降、头昏、疲乏无力也有效 (P <0 .0 5)。Obective To investigate the therapeutical effect of(SPD) on neurasthenia.Methods Twenty-nine neurastheniac patients were given stepholidine or placebo by double-blind trial;each patient received a dose of 50?mg SPD or placebo daily for 5wk and their symptoms were assessed with HAMD and SCL-90(Symptom Check List 90)before and after the treatment.Results SPD group showed better clinical effects(66.7% improved) than the control group(only 28%).SPD was significantly effective in relieving the symptoms of headache and insomnia(P<0.01)and of night mare and loss of concentration(P<0.05).Conclusion SPD is very effective to neurasthenia.

关 键 词：左旋千金藤立定碱 神经衰弱 疗效 

分 类 号：R749.71[医药卫生—神经病学与精神病学] R969[医药卫生—临床医学]