腺苷蛋氨酸治疗药物性肝病的疗效观察  

Therapeutic effect of adenosylmethionine on drug induced liver disease.

作　　者：唐善令[1] 史文丽[1] 赵蕊[1] 赵祥军[1] 

机构地区：[1]解放军第302医院感染科,北京100039

出　　处：《中国综合临床》2002年第12期1104-1105,共2页Clinical Medicine of China

摘　　要：目的探讨腺苷蛋氨酸治疗药物性肝病的疗效。方法治疗组 3 2例 ,在以甘利欣与能量合剂等护肝药物治疗的基础上同时加用腺苷蛋氨酸 ;对照组 3 0例 ,基础护肝药物及疗程与治疗组相同。观察并比较肝功能等生化指标的变化及副作用。结果治疗 4周后 ,治疗组 AST、TBi L、r-GT、AL P的改善情况及复常率明显优于对照组 ( P<0 .0 1) ;治疗组显效率及总有效率分别为 75 .0 %和 10 0 % ,明显高于对照组的 5 0 .0 %与 86.7% ( P<0 .0 5 )。结论腺苷蛋氨酸治疗药物性肝病具有较好的疗效。objective To investigate the therapeutic effect of adenosylmethoinine on drug induced liver diseases.Methods 32 cases in treatment group were given adenosylmethoinine on the basis of such liver protecting agents as Diammonium glycyrrhizinate and energy mixture.30 cases in control group took the same basic liver protecting agents for the same periods of the treatment as the treatment group.After that,some biochemical indexes reflecting liver function and side effect were observed and compared.Results 4 week treatment later,AST,TBiL,GGT and ALP as well as their recovery rates in treatment group were obviously better than those in the control group(P<0.01).The significantly effective rate and the overall effective rate in the treatment group were 75.0% and 100%,respectively,which were 50.0% and 86.75%,respectively,in control group ,remarkably higher than in control group (P<0.05) .Conclusion Adenosylmethionine can exert significant therapeutic effect on drug induced liver diseases.

关 键 词：疗效 药物性肝病 腺苷蛋氨酸 病因 肝功能 

分 类 号：R575.[医药卫生—消化系统]