青年期子宫内膜恶性肿瘤临床及病理分析  

Analysis of the clinical and pathological characteristics with endometrial malignancies in young women

作　　者：刘琦[1] 欧俊[1] 孟奎[2] 燕晓雯[2] 石群立[2] 

机构地区：[1]南京军区南京总医院南京大学医学院临床学院妇产科,江苏南京210002 [2]南京军区南京总医院南京大学医学院临床学院病理科,江苏南京210002

出　　处：《医学研究生学报》2002年第5期431-433,T003,共4页Journal of Medical Postgraduates

摘　　要：目的 :观察青年期子宫内膜恶性肿瘤的临床与病理特点。　方法 :回顾性分析 13例 4 0岁以下患者的子宫内膜恶性肿瘤临床、病理资料及行雌激素受体 (ER)、孕酮受体 (PR)免疫组化标记。　结果 :13例青年期子宫内膜恶性肿瘤患者年龄为 2 2～ 39岁 ,病理形态包含四种类型 ,其中子宫内膜样腺癌 8例 ,免疫组化标记示 6例ER和PR阳性 ,均为分化好的子宫内膜样腺癌。 8例子宫内膜样腺癌中 1例死亡 ,7例健在。其中 1例经保守治疗痊愈 ,1例经保守治疗后分娩 ;其余病理类型 (子宫内膜间质肉瘤或转移性肿瘤 )的 5例患者中 4例死亡。　结论 :青年期子宫内膜恶性肿瘤病理类型复杂 ,以子宫内膜样腺癌多见。ER、PR阳性、分化好的子宫内膜样腺癌预后较好 ,早期患者可通过保守治疗痊愈 ,甚至可生育 ,而低分化腺癌。Objectives: To investigate the clinical and pathological characteristics of endometrial malignancies in young women. Methods:Thirteen cases of endometrial malignancies in young women were respectively analyzed about the clinical records, pathological records and the immunohistochemical marks in ER and PR. Results:The patients' age ranged from 22~39 years. The pathological form of 13 cases included four types, among which there were eight cases of endometrioid adenocarcinoma. The immunohistochemical marks: six cases were positive in ER and PR, which were all well differential endometrioid adenocarcinoma. Follow up: In eight cases of endometrioid adenocarcinoma, one was dead, seven were survival, in which one was completely cured by conservative treatment, and one labored by conservative treatment. In the five cases of the other pathological types (endometrial stromal sarcoma or transformational type), four were dead. Conclusions:The incidence of endometrial malignancies in young women is increasing. Its pathological type is complex, in which the endometrioid adenocarcinoma is commonly seen. The prognosis of well differential endometrioid adenocarcinoma which is positive in ER and PR is better. The patients of extreme early phase carcinoma can be completely cured and even brought up by conservative treatment. While the prognosis of special malignancies, such as endometrial stromal sarcoma or transformational type et al , is bad.

关 键 词：青年期 子宫内膜恶性肿瘤 临床 病理 

分 类 号：R737.33[医药卫生—肿瘤]