肺癌患者骨髓微小转移灶的检测及其临床意义  

Detection of micrometastasis in the bone marrows in lung cancers

作　　者：陈龙邦[1] 臧静[1] 张群[1] 王靖华[1] 褚晓源[1] 耿怀成[1] 

机构地区：[1]南京军区南京总医院肿瘤科,江苏南京210002

出　　处：《医学研究生学报》2002年第5期434-435,T003,共3页Journal of Medical Postgraduates

摘　　要：目的 :检测肺癌患者骨髓微小转移灶 ,并探讨其临床意义。　方法 :用免疫组化法检测肺癌患者骨髓上皮膜抗原 (EMA)阳性表达细胞 ,分析其与肺癌病理类型、分期及远处转移的关系。　结果 :112例肺癌患者中 36例骨髓检出EMA阳性细胞 ,阳性率为 32 .1%。EMA阳性细胞的检出率与病期及远处转移有关 ,晚期及已发生转移的病例检出率明显增高。　结论 :骨髓EMA表达阳性细胞的检测 ,可作为评价肺癌患者病期及转移倾向的重要指标之一。Objectives:To study the relationship among the bone marrow micrometastasis,the clinical stages and the general metastasis in lung cancers. Methods:The bone marrow epithelial membrane antigen (EMA) positive cells from patients with lung cancers were measured by immunocytochemical assay by an antibody probe. Results:EMA positive cells were detected in the bone marrows in 36 patients (32.1%), the positive rates correlated with the stages of patients, and the recurrence rate in patients with remote metastasis were higher than those without bone marrow metastasis. Conclusions: The detection of EMA positive cells is important in evaluating the stage of patients with lung cancers and also to evaluate the possibility of recurrence and genenral metastasis.

关 键 词：肺癌 骨髓微小转移灶 检测 临床意义 免疫组化 上皮膜抗原 

分 类 号：R734.2[医药卫生—肿瘤]