肝硬化患者大脑基底节和白质磁化转移率测量研究  

Measurement Study of Magnetization Transfer Ratio of Basal Ganglion and White Matter of Cerebrum in the Patients with Liver Cirrhosis

作　　者：付建新[1] 李坤成[2] 王蕊[2] 张旭[1] 赵富强[1] 

机构地区：[1]首都医科大学生物医学工程学院,北京100053 [2]首都医科大学宣武医院放射科

出　　处：《中国医学影像技术》2002年第10期1024-1026,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的　应用磁化转移率测量对肝硬化患者头颅MRIT1加权像基底节和大脑白质高信号进行定量分析。方法　对 2 2例肝硬化患者和 18例健康成人志愿者行MRI扫描 ,并对苍白球、壳核、尾状核头、丘脑和大脑三角区白质 5个部位行磁化转移率的测量和计算。结果　 15例肝硬化患者T1加权像可见基底节区信号增高 ,7例未见信号明显异常。在苍白球、壳核和三角区脑白质部位 ,肝硬化患者与正常人的磁化转移率的差别有高度统计学意义。经单因子判别分析发现 ,苍白球的磁化转移率测量值鉴别肝硬化患者与正常人的敏感性、特异性和准确性最高。结论　肝硬化患者基底节和脑白质磁化转移率降低。Objective To quantitatively analyze magnetization transfer ratios of basal ganglion and white matter of cerebrum,which were detected as high signal intensity on T 1 weighted images,in the patients with liver cirrhosis. Methods Twenty two patients with liver cirrhosis and 18 healthy adult volunteers were examined by MRI and the magnetization transfer ratios were measured and calculated in five different regions including globus pallidus,putamen,head of caudate nucleus,thalamus and white matter of trigone of cerebrum. Results The magnetization transfer ratios of patients with liver cirrhosis were significantly lower than those of normal subjects.By single factor discriminant analysis,the sensibility,specificity and accuracy of the value of magnetization transfer ratios in globus pallidus were believed to be the highest. Conclusion Of patients with liver cirrhosis,lower magnetization transfer ratios can be found in basal ganglion and white matter of cerebrum.

关 键 词：大脑 基底节 白质 肝硬化 磁共振 磁化转移率 定量分析 MRI 

分 类 号：R575.2[医药卫生—消化系统] R445.[医药卫生—内科学]