胚胎肾上腺分化过程视黄酸受体表达及神经母细胞瘤发生的关系探讨  

Expression of retinoid acid receptors in embryonal adrenal gland and its relationships to neuroblastoma

作　　者：高解春[1] 王尔松[1] 杨毅[1] 陈莲[1] 

机构地区：[1]复旦大学附属儿科医院外科,上海200032

出　　处：《中华小儿外科杂志》2002年第6期546-548,共3页Chinese Journal of Pediatric Surgery

摘　　要：目的　探讨视黄酸受体在胚胎肾上腺分化过程中的表达及其对神经母细胞瘤发生的可能作用机制。方法　以原位杂交方法测定 2 0例胎儿肾上腺和 5例神经母细胞瘤的视黄酸受体RARα、β、γ和RXRα、β、γ ,并以阳性细胞光密度值作统计分析。结果　视黄酸受体阳性集中显示于神经母细胞结节 ,随胎龄增加表达增强 ,胚胎 19周后表达减弱 ;在分化不良型神经母细胞瘤中的视黄酸受体表达强度明显高于分化良好型。结论　视黄酸受体参与了肾上腺神经母细胞的分化过程 。Objective To establish the relationship between retinioc acid receptors and tumorigenesis of neuroblastoma. Methods Retinioc acid receptors (RARα,RARβ,RARγand RXRα,RXRβ,RXRγ) in 20 fetal adrenal glands and 5 neuroblastoma specimens were studied using in situ hydridization. The cellular optical densities were analyzed. Results The retinoic acid receptors (RAR) were expressed in neuroblastoma. RAR expression was stronger in unfavorable neuroblastoma. Conclusion RAR plays a role in the differentiation of adrenal neuroblastoma and is highly related to degree of tumor differentiation.

关 键 词：胚胎 肾上腺分化 视黄酸受体 神经母细胞瘤 细胞分化 相关性 原位杂交法 

分 类 号：R730.2[医药卫生—肿瘤]