反流性食管炎的临床研究  

A clinical study of reflux oesophagites

作　　者：姜佳丽[1] 王虹[1] 王敏丽[1] 王天佑[1] 毕春山[1] 刘宾[1] 

机构地区：[1]首都医科大学附属北京同仁医院消化内科,100730

出　　处：《中华内科杂志》2002年第12期822-824,共3页Chinese Journal of Internal Medicine

基　　金：北京市科委科研基金资助项目 (95 40 2 470 0 )

摘　　要：目的　探讨酸及胆汁反流在胃食管反流病 (GERD)中的发生情况及二者在GERD发病中的作用。方法　对 5 2例有反流症状的患者行内镜检查及 2 4hpH值和胆汁反流检测。结果　 5 2例受检者中 ,42例测得明显反流 ,其中混合反流占 5 9 5 % (2 5 /4 2 ) ,单纯反流仅占 40 5 % (17/4 2 )。在单纯反流中 ,以单纯酸反流为主 ,占 76 4% (13 /17) ;在混合反流中 ,以酸反流为主 ,反流程度较重 ,胆汁反流程度较轻 ;反流性食管炎在混合反流中的比例显著大于单纯酸反流 (P <0 0 5 ) ,且混合反流中的食管炎显著重于单纯反流 (P <0 0 5 ) ;反流症状发生的频率及严重程度与酸反流指数呈线性相关。结论　GERD中以混合反流为主 ;在混合反流及单纯反流中均以酸反流为主。酸反流和胆汁反流存在正性协同作用。Objective To study the incidence and role of acid and bile reflux in gastroesophageal reflux disease(GERD) Methods Fifty two patients with reflux symptoms were studied All of them were performed endoscopy received acid and bile reflux monitoring Results Fifty two patients received acid and bile reflux monitoring, 42 patients had reflux with the main type of double reflux (both acid and bile reflux) which was 59 5% (25/42), and with the type of the single reflux which was 40 5% (17/42) Among single reflux ,the acid reflux was the main type about 76 4% (13/17); Among double reflux, the degree of acid reflux was more severe,than did bile reflux; The percent of reflux oesophagites join the double reflux patients was significant high than that in single acid reflux patients( P <0 05); There was a liner correlation between acid reflux index either the frequency or the severity of reflux symptoms Conclusions Double reflux was the main type of reflux in GERD, and acid reflux was the main type among double reflux and single reflux There may be a synergistic effect between acid and bile reflux Acid reflux was the main factor for reflux symptoms

关 键 词：反流性食管炎 胃食管反流 胆汁反流 GERD 诊断 

分 类 号：R571[医药卫生—消化系统]