CCL2和VCAM-1在中枢神经系统白血病中的意义  

Significance of CCL2 and VCAM-1 in Central Nervous System Leukemia

作　　者：董航[1] 姜广宇[1] 赵悦荣 王宇航[2] Dong Hang;Jiang Guangyu;Zhao Yuerong;Wang Yuhang(The First Affiliated Hospital,Jiamusi University,Jiamusi 154002;Jiamusi City Hospital of Traditional Chinese Medicine,Jiamusi 154002)

机构地区：[1]佳木斯大学附属第一医院,黑龙江佳木斯154002 [2]佳木斯市中医院,黑龙江佳木斯154002

出　　处：《广东化工》2019年第5期105-106,共2页Guangdong Chemical Industry

基　　金：佳木斯大学面上项目课题编号:JMSUJCMS2016-066;黑龙江省卫生计生委课题编号:2016-291

摘　　要：目的探讨CCL2和VCAM-1在中枢神经系统白血病(CNSL)中的意义。方法应用ELISA方法检测对照组(非白血病)、非-CNSL组(No-CNSL)、CNSL组病人血液、脑脊液中CCL2和VCAM-1的水平;应用RT-PCR检测骨髓中CCL2和VCAM-1mRNA的表达。结果 CNSL组脑脊液中CCL2、VCAM-1的含量以及骨髓CCL2、VCAM-1mRNA的表达高于No-CNSL组,有显著性差异(p<0.05)。结论脑脊液和骨髓中CCL2和VCAM-1检测对中枢神经系统白血病预后具有指导意义。Objective To investigate the significance of CCL2 and VCAM-1 in Central Nervous System Leukemia(CNSL). Methods The levels of CCL2 and VCAM-1 in blood and cerebrospinal fluid of patients in control group(non-leukemia), non-CNSL group(no-CNSL) and CNSL group were detected by ELISA, and the expressions of CCL2 and VCAM-1 mRNA in bone marrow were detected by RT-PCR. Results The levels of CCL2 and VCAM-1 in cerebrospinal fluid and the expression of CCL2 and VCAM-1 mRNA in bone marrow of CNSL group were higher than those of No-CNSL group(p < 0.05). Conclusion The detection of CCL2 and VCAM-1 in cerebrospinal fluid and bone marrow has guiding effect ion for the prognosis of central nervous system leukemia.

关 键 词：CCL2 VCAM-1 中枢神经系统白血病 

分 类 号：R733.71[医药卫生—肿瘤] R747.9[医药卫生—临床医学]