血清降钙素原和C反应蛋白联合检测在急性胰腺炎危重度的早期评估及治疗的价值  

Early clinical values of serum procalcitonin and C-reactive protein with severity and treatment of acute pancreatitis

作　　者：王学新[1] 聂晓辉[1] 田亚兰 丁刚 马杰 王辉 陈薇[1] 

机构地区：[1]阿克苏地区第一人民医院急诊外科,阿克苏843000 [2]阿克苏市人民医院

出　　处：《肝胆外科杂志》2015年第6期448-450,共3页Journal of Hepatobiliary Surgery

摘　　要：目的探讨联合检测血清血清降钙素原(PCT)和C反应蛋白(CRP)对急性胰腺炎严重程度的早期判断价值及抗生素治疗指导价值。方法收集AP患者73例,其中重症胰腺炎(SAP)21例,轻症急性胰腺炎(MAP)52例,以及正常对照20例,分别在入院后第1、2、3、4天动态监测各位患者PCT和CRP水平,分析这些指标与AP严重程度及预后关系。结果MAP组和SAP组患者血清PCT及CRP水平均高于对照组(均P<0.05),SAP组患者同期PCT及CRP水平均高于MAP组(均P<0.05)。结论血清PCT和CRP能够在早期反映急性胰腺炎患者的病情严重程度,并且能够反映AP患者是否合并感染,有助于早期判断疾病的严重程度和早期合理预防感染,对AP的早期综合治疗具有一定的临床指导价值。Objective To investigate the early predictive of the combined detection of procalcitonin( PCT) and C-reaction protein( CRP) in the severity of acute pancreatitis( AP). Methods The enrolled included 21 eases of the severe AP( SAP),52 Cases of mild AP( MAP),and 20 cases of normal controls. The levels of PCT and CRP in each group were dynamically detected respectively at 1st,2rd,3th and 4th day after admission,and the correlations between these indexes and the severity and proguosis of AP were analyzed.Results The levels of serum PCT and CRP in acute pancreatitis patients were significantly higher than those of control group( all P <0. 05),PCT and CRP levels in patients with SAP group were higher than those in the same period of MAP group( all P < 0. 05). Conclusions Serum levels of PCT and CRP can not only reflect the serious of acute pancreatitis at the early stage but also determine whether AP is combined with infection. Therefore,determination of serum PCT and CRP levels can be used to diagnose the severity of the disease and help the early prevention of infection,thus has an important clinical value.

关 键 词：降钙素原 C-反应蛋白 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]