原发性胃T细胞淋巴瘤的临床病理分析  

Clinicopathologic analysis of primary gastric T cell lymphoma

作　　者：姚楠[1] 孙景秋[2] 郭冰沁[1] 

机构地区：[1]蚌埠医学院第一附属医院病理科,蚌埠医学院病理学教研室 [2]蚌埠医学院第一附属医院核医学科,蚌埠233003

出　　处：《中国组织化学与细胞化学杂志》2015年第6期591-595,615,共6页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：目的分析探讨原发于胃的外周T细胞淋巴瘤(Primary gastric T cell lymphoma,PTCL)的临床病理特征、免疫表型及分子生物学特点。方法回顾分析我院自2009~2012年收治的经免疫组化证实的PTCL患者4例。结合临床表现、形态学特征、发病机制和免疫表型,对其进行分析,并对鉴别诊断、治疗和预后的情况进行讨论。结果原发于胃的PTCL临床表现为腹胀、腹痛、腹部包块;镜下见形态较单一的肿瘤性淋巴细胞弥漫分布,穿插于肌间;免疫表型肿瘤细胞均表达T细胞标记,部分病例细胞毒标记(TIA-1)可阳性。治疗手段以手术切除辅以联合化疗为主,预后较差。结论 PTCL原发于胃非常罕见,这是一类异质性很强的肿瘤,必须结合临床、病理组织特征和免疫组织化学特征进行诊断和鉴别诊断。Objective To study the clinical pathologic,immunophenotypic and molecular biological characteristics of primary gastric T cell lymphoma( PTCL). Methods 4 cases of PTCL were reported and the relevant literature was reviewed. Analysis of its clinical manifestations, morphology, pathogenesis and immune phenotype was followed by discussion of its differential diagnosis, treatment and prognosis. Results The clinical manifestations of PTCL were bloating, abdominal pain and abdominal mass. All of the tumor cells expressed T cell markers; in some cases the T cell intracellular antigen 1( TIA-1) was positive. Treatment consisted in surgical resection combined with chemotherapy, but the prognosis was poor. Conclusion PTCL in the stomach is very rare, which is a class of highly heterogeneous tumor. Diagnosis and differential diagnosis must be based on clinicopathological and immunohistochemical features.

关 键 词：原发性胃恶性淋巴瘤 外周T细胞淋巴瘤非特殊型 临床病理学 免疫组化染色 

分 类 号：R735.2[医药卫生—肿瘤]