心脏的抑制性β-肾上腺素受体  

Inhibitory β-adrenergic receptor in heart

作　　者：徐琦[1] 董尔丹[1] 陈锴[1] 韩启德[1] 

机构地区：[1]北京大学第三医院血管医学研究所,北京100083

出　　处：《中国病理生理杂志》2002年第12期1544-1547,共4页Chinese Journal of Pathophysiology

摘　　要：adrenergic receptor is the third subtype of β-adrenergic receptors. The genetic structure and pharmacological property of β 3-adrenergic receptor are markedly distinguished from β 1-and β 2-adrenergic receptor subtypes. Recently studies show that myocardial β 3-adrenergic receptor mediates negative inotropic effect through Gi-protein/NO/cGMP pathway, the expression of β 3-adrenergic receptor and negative inotropic effect mediated by β 3-adrenergic receptor are increased in heart failure. However, because of the low expression of β 3-adrenergic receptor in the heart, the actual pathophysiological significance of β 3-adrenergic receptor remains unknown.adrenergic receptor is the third subtype of β-adrenergic receptors. The genetic structure and pharmacological property of β 3-adrenergic receptor are markedly distinguished from β 1-and β 2-adrenergic receptor subtypes. Recently studies show that myocardial β 3-adrenergic receptor mediates negative inotropic effect through Gi-protein/NO/cGMP pathway, the expression of β 3-adrenergic receptor and negative inotropic effect mediated by β 3-adrenergic receptor are increased in heart failure. However, because of the low expression of β 3-adrenergic receptor in the heart, the actual pathophysiological significance of β 3-adrenergic receptor remains unknown.

关 键 词：肾上腺素能Β受体 心脏 基因 结构 

分 类 号：R331.31[医药卫生—人体生理学]