胃起搏对胃动力紊乱模型犬胃排空的影响  

Effects of gastric pacing on gastric emptying in a canine model of gastric motor disorders

作　　者：杨敏[1] 房殿春[1] 龙庆林[1] 隋建峰[2] 李前伟[3] 孙念绪[4] 甘露[4] 

机构地区：[1]第三军医大学附属西南医院全军消化专科中心 [2]第三军医大学基础医学部生理学教研室 [3]第三军医大学附属西南医院核医学中心 [4]第三军医大学附属西南医院普通外科,重庆400038

出　　处：《第三军医大学学报》2002年第12期1449-1450,共2页Journal of Third Military Medical University

基　　金：西南医院创新基金资助项目 ( 2 0 0 1院 )

摘　　要：目的　研究胃起搏对胃动力紊乱模型犬胃排空的影响。方法　采用双侧迷走神经干切断术联合应用胰高血糖素建立胃动力紊乱犬模型 ;采用放射性核素99Tcm 植酸钠标记的半固体试餐 ,单光子放射计算机断层显象术 (SPECT)检测胃半排空时间(GEt1 2 ) ;采用适应起搏参数从位表输入起搏信号以驱动胃电节律。结果　迷走神经干切除术后犬的GEt1 2 (79.42± 1.91)min较术前 (5 6.3 5± 2 .99)min ,(P <0 .0 0 1) ,明显延迟 ,但行胃起搏治疗后GEt1 2 (64 .94± 1.75 )min ,显著低于治疗前 (P <0 .0 0 1)。结论　采用适宜起搏参数进行胃起搏可加速胃排空 。Objective To investigate the effects of surface gastric pacing on gastric emptying in a canine model of gastric motor disorders. Methods A model of gastric motor disorders was established by truncal vagotomy combined with injections of glucagons. Gastric half emptying time (GE t1/2 ) was monitored and analysed using single photon emission computerized tomography (SPECT), and the half solid test meal was labeled with an isotope 99 Tc m sulfur colloid. Surface gastric pacing using the optimal pacing parameters was applied to entrain gastric slow wave. Results Compared with that before surgery, GE t1/2 of model dogs with vagotomy increased significantly from (56.35±2.99) min to (79.42±1.91) min( P <0.001), but after gastric pacing, GE t1/2 (64.94±1.75) min of model dogs was markedly shorter than that of pretreatment( P < 0.001). Conclusion Surface gastric pacing using the optimal pacing parameters can significantly accelerate gastric emptying and resume or alter motor function. Surface gastric pacing may prove to be a new therapeutic approach for treatment of gastric motor disorders.

关 键 词：胃起搏 胃轻瘫 胰高血糖素 胃排空 迷走神经干切断术 胃动力紊乱 

分 类 号：R573[医药卫生—消化系统]