立体定向毁损杏仁核簇不同亚核团和扣带回前区治疗难治性精神分裂症  

THERAPEUTICS EFFECT OF INTRACTABLE SCHIZOPHRENIA BY LESIONING DIFFERENT SUBNUCLEUES OF AMYGDALA AND FRONT PART OF CALLOSAL GYRUS WITH STEREOTACTIC TECHNIQUE

作　　者：李拴德[1] 李涛[1] 王晓峰[1] 姜克明[1] 杨来启[1] 胡淑芳[1] 吴兴曲[1] 

机构地区：[1]解放军第3医院

出　　处：《解放军医学杂志》2002年第12期1076-1077,共2页Medical Journal of Chinese People's Liberation Army

基　　金：全军临床高新技术重大项目;全军"十五"医学科研面上项目资助课题(编号 0 1MA0 1 9)

摘　　要：采用CRW立体定向仪和PICKER螺旋CT定位 ,用RADONICS毁损仪毁损杏仁核不同亚核团和扣带回前部治疗精神分裂症 3 5例 ,并进行了一年的随访。以临床疗效总评量表 (CGI)评定疗效标准为指标 ,评定病人疗效 ,旨在探讨立体定向毁损杏仁核不同亚核团和扣带回治疗难治性精神分裂症的可行性和疗效。用WEISS量表对 3 5例病人手术前后的智力进行评定 ,总疗效评定结果 :显著进步 2 1例 ,进步 8例 ,稍进步 5例 ,无变化 1例 ,无恶化者 ;手术后病人的智力未见明显损害。结果提示 。To investigate feasibility and effect of schizophrenia treatment by stereotactic lesioning, CRW stereotactic apparatus and PICKER spiral CT were used to define nucleus location and RADONICS radiofrequency instruments were used to lesion different subnucleuses of amygdala and the front part of callosal gyrus. All schizophrenic patients were diagnosed by ICD Ⅲ standards, In cases with one year followup ,the effect were analysed with Global Improvement (GI) scoring. In this group , 21 cases were significantly improved , 8 cases improved, 3 cases slightly improved, 1 case unchanged, and 0 case deteriorated. These results suggest selective lesioning subnucleus of amygdala according to different symptoms of schizophrenia could improve the curative effect of surgical treatment for schizophrenia.

关 键 词：杏仁核 扣事回前区 立体定向核团毁损术 治疗 难治性精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]