多巴胺对严重烫伤大鼠血清乳酸、一氧化氮水平的影响  

EFFECTS OF DOPAMINE ON LACTIC ACID AND NITRIC OXIDE IN SCALDED RATS SERUM

作　　者：潘文东[1] 周明[1] 杨正文[1] 李木惠[1] 张道全[1] 

机构地区：[1]解放军第59医院

出　　处：《解放军医学杂志》2002年第12期1094-1095,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：大鼠预置心导管 ,3 0 %Ⅲ度烫伤后静脉复苏 ,观察多巴胺 [3 μg/(kg·min) ]持续给药后大鼠的血清乳酸、一氧化氮 (NO)水平的变化。结果显示 ,与对照组相比 ,多巴胺治疗能显著降低严重烫伤大鼠血清中的乳酸、NO水平 ,以伤后 3～ 12h明显。研究表明 ,多巴胺可降低严重烫伤大鼠休克期血清乳酸、NO水平。To investigate the effects of dopamine on lactic acid and nitric oxide in severe scalded rats′ serum, 30%TBSA (total body surface area) scalded rats were placed with cardiac catheters and intravenously resuscitated with dopamine [3μg/kg·min], then the contents of lactic acid and nitric oxide in serum were measured. The results showed that treated rats have significant low serum lactic acid and nitric oxide contents than those of the control rats, especially at 3 to 12 hours after scald. Therefore, dopamine could reduce the serum lactic acid and nitric oxide contents of scalded rats in shock stage.

关 键 词：多巴胺 烫伤 大鼠 血清 乳酸 一氧化氮 休克 

分 类 号：R644[医药卫生—外科学]